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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (10): 1285-1287. 上一篇    下一篇

研究简报

2-(取代氨基硫代甲酰基)-3,4,5,6-四氢嘧啶的合成

刘玮炜*,a，唐丽娟a，曾艳霞a，王玲a
赵跃强a，陈克潜b，陆忠娥b   

  1. (a淮海工学院化工系 连云港 222005)
    (b苏州大学化学系 苏州 215123)
  • 收稿日期:2006-09-07 修回日期:2006-12-28 发布日期:2007-09-28
  • 通讯作者: 刘玮炜

Synthesis of 2-(Substituted aminothiocar-bonyl)-3,4,5,6-tetrahydropyrimidines

LIU Wei-Wei*,a,TANG Li-Juan a, ZENG Yan-Xia a,WANG Linga
ZHAO Yue-Qiang a, CHEN Ke-Qianb,LU Zhong-Eb   

  1. (a Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005)
    (b Department of Chemistry, Suzhou University, Suzhou 215123)
  • Received:2006-09-07 Revised:2006-12-28 Published:2007-09-28
  • Contact: LIU Wei-Wei

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以N,N'-二取代二硫代草酰胺与1,3-丙二胺在DMSO中进行缩合反应, 合成了一系列2-取代氨基硫代甲酰 基-3,4,5,6-四氢嘧啶, 反应在2 h内完成, 产率56%～76%. 产物结构经元素分析, IR, 1H NMR及MS确证.

关键词: N,N'-二取代二硫代草酰胺, 1,3-丙二胺, 合成, 2-(取代氨基硫代甲酰基)-3,4,5,6-四氢嘧啶

series of 2-substituted aminothiocarbonyl-3,4,5,6-tetrahydropyrimidine compounds were synthesized by the condensation reaction of N,N'-disubstituted dithiooxamide with 1,3-propylenediamine in DMSO. The reactions were completed in 2 h with the yields of 56%～76%. The structures of the products were established by elemental analysis, IR, 1H NMR and MS spectra.

Key words: 1,3-propylenediamine, 2-(substituted aminothiocarbonyl)- 3,4,5,6-tetrahydropyrimidine, synthesis, N,N'-disubstituted dithiooxamide