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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (9): 1412-1418. 上一篇    下一篇

研究论文

1,5-二取代吡唑基-1,4-戊二烯-3-酮类化合物的合成及生物活性研究

王振宁 胡德禹 宋宝安* 杨 松 金林红 薛 伟   

  1. (贵州大学精细化工研究开发中心 教育部绿色农药与农业生物工程重点实验室 贵阳 550025)
  • 收稿日期:2008-07-27 修回日期:2009-01-13 发布日期:2009-12-30
  • 通讯作者: 宋宝安

Synthesis and Biological Activity of 1,5-Bis(substituted pyrazol-4-yl)- 1,4-pentadien-3-one Derivatives

Wang, Zhenning Hu, Deyu Song, Baoan* Yang, Song Jin, Linhong Xue, Wei   

  1. (Key Laboratory of Green Pesticide and Agriclutural Bioengineering, Ministry of Education, Research and Development
    Center for Fine Chemicals, Guizhou University, Guiyang 550025)
  • Received:2008-07-27 Revised:2009-01-13 Published:2009-12-30
  • Contact: Song, Baoan

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被引次数

22 | 6

设计合成了13个未见文献报道的1,5-二取代吡唑基-1,4-戊二烯-3-酮类化合物, 其结构经元素分析, 1H NMR, IR确证. 初步生物活性测试结果表明, 部分化合物有一定的抗烟草花叶病毒(TMV)活性, 所有化合物抑菌活性较低.

关键词: 1,4-戊二烯-3-酮类衍生物, 吡唑, 合成, 生物活性

In order to find novel anti-TMV and antifungal compounds with high activity and low toxicity, thirteen new 1,5-bis(substituted pyrazol-4-yl)-1,4-pentadien-3-one derivatives were synthesized. Their structures were characterized by IR, 1H NMR spectra and elemental analysis. Preliminary bioassays indicated that some compounds showed moderate activity against TMV, and all compounds showed weak antifungal activity.

Key words: pyrazole, systhesis, bioactivity, 1,4-pentadien-3-one derivative