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有机化学
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有机化学 ›› 1990, Vol. 10 ›› Issue (3): 233-236. 上一篇    下一篇

研究论文

2'-脱氧-2'-氟-2'-尿嘧啶-3',4'-０－异亚丙基-L-阿拉伯糖甲苷的合成

马灵台;杨宽斌;董领娇;张礼和   

  1. 北京医科大学药学院
  • 发布日期:1990-06-25

Synthesis of methyl 2'-deoxy-2'-fluoro-2'-uracil-3',4'-O-isopropylidene-L-arabinoside

MA LINGTAI;YANG KUANBIN;DONG LINGJIAO;ZHANG LIHE   

  • Published:1990-06-25

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471

本文报道以L-阿拉伯糖为原料, 将所得的偕二氟代糖在BF3.εt2O催化下,直接与硅烷化尿嘧啶缩合, 得到相应的L-构型的2'-脱氧-2'-氟-2'-尿嘧啶异核苷。所得产物经UV. 1H NMR、^1^9F NMR和MS证明。

关键词: 紫外分光光度法, 氟代烃, 氟脲嘧啶, 核苷, 质谱法, 质子磁共振谱法, 异丙基, 脱氧核糖核苷, 氟19核磁共振谱法, 阿拉伯糖

Deoxydifluoropentopyranosides I (R = F) was reacted with trimethylsilylated uracil to give title compounds I (R = uracil) (II). None of these isonucleosides II showed antitumor activity.

Key words: FLUOROURACILUM, ULTRAVIOLET SPECTROPHOTOMETRY, MASS SPECTROGRAPHY, FLUOROHYDROCARBON, NUCLEOSIDE, PROTON MAGNETIC RESONANCE SPECTROMETRY, ISOPROPYL GROUP, F19 NMR SPECTROMETRY, DEOXYRIBONUCLEOSIDES, ARABINOSE

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