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有机化学 ›› 2008, Vol. 28 ›› Issue (01): 111-114. 上一篇    下一篇

研究简报

新型溴代羟基二苯醚的合成及抑菌活性研究

邹燕a，吴洁c，侯若彤b，吴凯群*,a
王玉良a，陈淑华a，杨志荣b，王玉忠a   

  1. (a四川大学化学学院 成都 610064)
    (b四川大学生命科学学院 成都 610064)
    (c东北大学信息科学与工程学院 沈阳 110044)
  • 收稿日期:2006-11-23 修回日期:1900-01-01 发布日期:2008-01-23
  • 通讯作者: 吴凯群

Study on the Synthesis and Bactericidal Activities of New Brominated Hydroxy Diphenyl Ether

ZOU Yana, WU Jiec, HOU Ruo-Tongb, WU Kai-Qun*,a, WANG Yu-Lianga
CHEN Shu-Huaa, YANG Zhi-Rongbsup>a, WANG Yu-Zhong<   

  1. (a College of Chemistry, Sichuan University, Chengdu 610064)
    (b College of Life Science, Sichuan University, Chengdu 610064)
    (c College of Infor-mation Engineering, Northeastern University, Shengyang 11044)
  • Received:2006-11-23 Revised:1900-01-01 Published:2008-01-23
  • Contact: WU Kai-Qun

PDF

779

被引次数

14

设计并合成了10个新的溴代羟基二苯醚, 所有这些化合物的结构均经过1H NMR, MS, IR和元素分析所证实. 新化合物的结构避免了现有卤代2-羟基二苯醚杀菌剂在生产和使用过程中有可能生成高毒性二噁英类化合物的缺点. 选择几种有害菌对合成的溴代羟基二苯醚进行了抑菌活性检测, 证实它们对所测试菌种具有优良的抑制效果.

关键词: 溴代4-羟基二苯醚, 合成, 抑菌活性

Ten new brominated hydroxy diphenyl ethers have been designed and synthesized via etherification of phenols with para-hydroxyphenyl chloride and bromination of the formed diphenyl ethers. Their structures have been confirmed by 1H NMR, IR, mass spectra and elemental analysis. These new compounds will not generate dioxins during their manufacture and use. The bioactivity test showed that these compounds possessed good antimicrobial activities toward the tested bacteria.

Key words: synthesis, brominated 4-hydroxy diphenyl ether, antimicrobial activity