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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (2): 335-338. 上一篇    下一篇

研究简报

水溶性氧杂酰胺类化合物的合成及表征

张平*，王海荣，王建晨，陈靖   

  1. (清华大学核能与新能源技术研究院 北京 102201)
  • 收稿日期:2006-05-23 修回日期:2007-08-25 发布日期:2008-02-01
  • 通讯作者: 张平

Synthesis and Characterization of Water-Soluble Oxa-amide Compounds

ZHANG Ping*,WANG Hai-Rong,WANG Jian-Chen,CHEN Jing   

  1. (Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 102201)
  • Received:2006-05-23 Revised:2007-08-25 Published:2008-02-01
  • Contact: ZHANG Ping

PDF

1287

被引次数

15

以二甘醇为原料, 经氧化得到的二甘酸, 通过氯代或缩合反应得到中间体酰氯和酸酐, 二烷基胺在吡啶催化下与酰氯或酸酐发生胺解反应, 合成出系列水溶性氧杂单酰胺及氧杂双酰胺, 包括N,N-二烷基-3-氧杂-戊酰胺酸系列和N,N,N'N'-四烷基-3-氧杂-戊二酰胺系列(烷基包括甲基、乙基和丙基). 用IR和1H NMR对合成的目标产物进行了表征.

关键词: 水溶性氧杂单酰胺, 氧杂双酰胺, 合成, 表征

Diglycolic anhydride or diglycolic acyl chloride was prepared by the oxidation of diethylene glycol followed by dehydration or chloro-substitution. By reaction between diglycolic anhydride or diglycolic acyl chloride and dialkyl amine in the presence of pyridine as a catalyst, a series of novel water-soluble oxa-amide compounds, including N,N'-dialkyl-3-oxaglutaramic acid and N,N,N',N'-tetraalkyl-3-oxaglutar- amide (alkyl＝methyl, ethyl and propyl) were synthesized and identified with 1H NMR and IR spectra.

Key words: oxa-diamide, oxa-monoamide, synthesis, characterization