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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (03): 506-510. 上一篇    下一篇

研究简报

新型含吡唑基的查尔酮的合成、表征及晶体结构

解正峰a，貊雪霞a，刘方明*,a,b   

  1. (a新疆大学石油天然气精细化工教育部重点实验室 乌鲁木齐 830046)
    (b杭州师范大学材料与化学化工学院 杭州 310012)
  • 收稿日期:2007-04-25 修回日期:2007-07-12 发布日期:2008-03-18
  • 通讯作者: 刘方明

Synthesis, Characterization and Single Crystal Structures of Pyrazol-4-yl-contaning Chalcone Compounds

XIE Zheng-Fenga,MO Xue-Xiaa,LIU Fang-Ming*,a,b   

  1. (a Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education, Xinjiang University, Urumqi 830046)
    (b College of Material, Chemistry and Chemical En-gineering, Hangzhou Normal University, Hangzhou 310012)
  • Received:2007-04-25 Revised:2007-07-12 Published:2008-03-18
  • Contact: LIU Fang-Ming

PDF

827

被引次数

35

以2种1-苯基-3-甲基-5-对甲苯氧基-吡唑-4-甲醛为原料, 在强碱条件下与苯乙酮(取代苯乙酮)发生羟醛缩合, 高产率地合成出10种新型含吡唑基的查尔酮. 化合物的结构经元素分析, IR和1H NMR确认. 并用X射线衍射法测定了化合物4c的晶体结构. 化合物4c属三斜晶系, 空间群P-1, 晶胞参数: a＝1.0225(2) nm, b＝1.4263(3) nm, c＝1.6718(3) nm, α＝110.32(3)°, β＝106.30(3)°, γ＝98.11(3)°, Mr＝428.90, V＝2.1159(7) nm3, Dc＝1.346 Mg/m3, Z＝2, F(000)＝896.

关键词: 查尔酮, 吡唑, 晶体结构, 表征

Ten chalcones were synthesized by aldol condensation reaction of acetophenone or para-substituted acetophenones with 1-phenyl-3-methyl-5-phenoxylpyrazole-4-aldehyde in the strong alkali condition. The structures were characterized by elemental analysis, IR, 1H NMR spectra, and the structure of 4c was confirmed by X-ray single-crystal diffraction analysis. The crystal of the compound 4c belongs to triclinic, space group P-1 with cell parameters a＝1.0225(2) nm, b＝1.4263(3) nm, c＝1.6718(3) nm, α＝110.32(3)°, β＝106.30(3)°, γ＝98.11(3)°, Mr＝428.90, V＝2.1159(7) nm3, Dc＝1.346 Mg/m3, Z＝2, and F(000)＝896.

Key words: pyrazole, characterization, chalcone, crystal structure