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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (03): 521-524. 上一篇    下一篇

研究简报

N-[5-(2-氯苯基)-2-呋喃甲酰氨基硫羰基]-L-α-氨基酸乙酯的合成与生物活性测定

王庆东a,b，薛思佳*,a，申杰峰a，蔡志娟a   

  1. (a上海师范大学生命与环境科学学院 上海 200234)
    (b江苏省盐城师范学院化学化工学院 盐城 224002)
  • 收稿日期:2007-04-29 修回日期:2007-10-09 发布日期:2008-03-18
  • 通讯作者: 薛思佳

Synthesis and Bioactivity of N-[5-(2-Chlorophenyl)-2-furamidothiocarbonyl]-L-α-amino Acid Ethyl Esters

WANG Qing-Donga,b,XUE Si-Jia*,a,SHEN Jie-Fenga,CAI Zhi-Juana   

  1. (a College of Life and Environment Science, Shanghai Normal University, Shanghai 200234)
    (b School of Chemistry & Chemical Engineering, Yancheng Teachers Uni-versity, Yancheng 224002)
  • Received:2007-04-29 Revised:2007-10-09 Published:2008-03-18
  • Contact: XUE Si-Jia

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设计并合成了9种未见文献报道的N-(5-邻氯苯基-2-呋喃甲酰氨基硫羰基)-L-α-氨基酸乙酯衍生物, 其结构经IR, 1H NMR, MS和元素分析测试确证. MTT法测试结果表明大部分目标化合物对白血病K562细胞系的增殖具有明显的抑制作用.

关键词: L-α-氨基酸乙酯, K562细胞, 5-邻氯苯基-2-呋喃甲酸, 合成, 酰基硫脲

Nine novel N-[5-(2-chlorophenyl)-2-furamidothiocarbonyl]-L-α-amino acid ethyl esters were designed and synthesized . The structures of all target compounds were confirmed by IR, 1H NMR, MS spectra and elemental analysis. By MTT assay, most target compounds show the activity of restraining the proliferation of K562 cells in vitro.

Key words: 5-(2-chlorophenyl)-furan-2-carboxylic acid, acylthiourea, L-α-amino acid ester, K562 cell, synthesis