有机化学 ›› 2005, Vol. 25 ›› Issue (08): 972-976. 上一篇    下一篇

研究论文

1-(1-甲氧基-1-二茂铁基-3-芳基-丙烷-2-基)-1H-1,2,4-三唑类衍生物的合成及生物活性研究

金钟,刘伟,胡燕,刘建兵,邵玲,方建新*   

  1. (南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2004-10-29 修回日期:2005-03-08 发布日期:2005-07-30
  • 通讯作者: 方建新

Synthesis, Structure and Biological Activity of 1-(1-Methoxy-1-ferro-cenyl-3-arylpropan-2-yl)-1H-1,2,4-triazole Derivatives

JIN Zhong,LIU Wei,HU Yan,LIU Jian-Bing,SHAO Ling,FANG Jian-Xin*   

  1. (State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071)
  • Received:2004-10-29 Revised:2005-03-08 Published:2005-07-30
  • Contact: FANG Jian-Xin

通过在三唑类活性结构中引入较大空间位阻的二茂铁基设计合成了11个新颖的含二茂铁取代的1H-1,2,4-三唑类化合物, 其结构经元素分析, 1H NMR谱和单晶X-ray衍射分析得到确证. 初步的生物活性测试表明, 部分化合物具有明显的植物生长调节活性.

关键词: 1H-1,2,4-三唑, 二茂铁, 抗菌活性, 植物生长调节活性

Eleven new 1-(1-methoxy-1-ferrocenyl-3-arylpropan-2-yl)-1H-1,2,4-triazole derivatives have been synthesized from acetylferrocene. The structures of the title compounds have been determined by elemental analysis, 1H NMR and single crystal X-ray diffraction analysis. Bioassay showed that some of the title compounds had high plant-growth regulatory activity.

Key words: ferrocene, 1H-1,2,4-triazole, fungicidal activity, plant-growth regulatory activ-ity