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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (08): 977-981. 上一篇    下一篇

研究论文

含丝氨酸和组氨酸残基手性肽核酸单体的合成

孟庆国，褚征，刘克良*   

  1. (1军事医学科学院毒物药物研究所 北京 100850)
    (2烟台大学药学院 烟台 264005)
  • 收稿日期:2004-03-29 修回日期:2005-04-19 发布日期:2005-07-30
  • 通讯作者: 刘克良

Synthesis of Chiral Peptide Nucleic Acid Monomers ContainingSerine and Histidine Residues

MENG Qing-Guo,CHU Zheng,LIU Ke-Liang*   

  1. (1 Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850)
    (2 School of Pharmacy, Yantai University, Yantai 264005)
  • Received:2004-03-29 Revised:2005-04-19 Published:2005-07-30
  • Contact: LIU Ke-Liang

PDF

2176

被引次数

5

设计合成了含组氨酸残基碱基为胸腺嘧啶的手性肽核酸单体, 咪唑氨基的最终保护基为2,4-二硝基苯基(Dnp). 对文献合成方法进行了适当改进, 制备了两种含丝氨酸和组氨酸残基碱基为腺嘌呤的手性肽核酸单体, 以上化合物均可作为制备手性肽核酸的基本构建单元.

关键词: 肽核酸, 合成, 肽核酸单体, 组氨酸, 丝氨酸

A chiral peptide nucleic acid (PNA) monomer containing histidine residue and thymine has been designed and synthesized employing 2,4-dinitrofluorobenzene to protect the NH group of imidazole. Other two PNA monomers containing serine and histidine residues and adenine have been prepared with the modified method to literatures. These compounds could be used as building blocks for chiral peptide nucleic acid analogues.

Key words: peptide nucleic acid, serine, synthesis, histidine, PNA monomer