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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (11): 1406-1409. 上一篇    下一篇

研究论文

新型环烷烯并嘧啶并噻唑-3-酮类化合物的合成

胡晓芬，冯亚青*，苏琦   

  1. (天津大学化工学院精细化工系 天津 300072)
  • 收稿日期:2005-04-21 修回日期:2005-05-30 发布日期:2005-10-30
  • 通讯作者: 冯亚青

Synthesis of Novel Cycloal-keno[1,2-d]thiazolo[3,2-a]pyrimidin-3-ones

HU Xiao-Fen,FENG Ya-Qing*,SU Qi   

  1. (Department of Fine Chemicals, School of Chemical Engineering and Technology, Tianjin Univer-sity, Tianjin 300072)
  • Received:2005-04-21 Revised:2005-05-30 Published:2005-10-30
  • Contact: FENG Ya-Qing

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1481

被引次数

7

以环戊酮、环庚酮为起始原料合成的环烷烯并[1,2-d]嘧啶-2-硫酮(2)与氯乙酸、芳香醛反应, 合成具有潜在抗癌活性的稠合杂环化合物5-芳基-2,8-二芳亚甲基-2,3,6,7-四氢-5H,8H-环戊烯并[1,2-d]噻唑并[3,2-a]嘧啶-3-酮(3)以及5-芳基-2,10-二芳亚甲基-2,3,6,7,8,9-六氢-5H,10H-环庚烯并[1,2-d]噻唑并[3,2-a]嘧啶-3-酮(4). 3和4的结构经1H NMR, IR, MS分析确认.

关键词: 环烷烯并嘧啶并噻唑酮, 稠合杂环化合物, 合成, 表征

Two types of cycloalkeno[1,2-d]pyrimidin-2-thiones (2) reacted with chloroacetic acid and the appropriate aldehyde to give 5-aryl-2,8-bis(arylmethylene)-2,3,6,7-tetrahydro-5H,8H-cyclopenta[1,2-d]thi- azolo[3,2-a]pyrimidin-3-ones (3) and 5-aryl-2,10-bis(arylmethylene)-2,3,6,7,8,9-hexahydro-5H,10H-cyclo- hepta[1,2-d]thiazolo[3,2-a]pyrimidin-3-ones (4) respectively, which show potential anticancer activities. Structures of novel compounds 3 and 4 were determined by 1H NMR, IR and MS spectra.

Key words: cycloalkeno[1,2-d]thiazolo[3,2-a]pyrimidin-3-one, fused heterocyclic, synthesis, deter