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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (12): 1594-1598. 上一篇    下一篇

研究简报

含硫代酰胺新三唑类化合物的合成、结构表征及生物活性研究

许良忠*，李伟华，李凯，秦永其，李春丽，候宝荣   

  1. (1青岛科技大学化学与分子工程学院 青岛 266042)
    (2中国海洋大学化学化工学院 青岛 266033)
    (3中国科学院海洋研究所 青岛 266071)
  • 收稿日期:2005-01-14 修回日期:2005-06-20 发布日期:2005-11-30
  • 通讯作者: 许良忠

Studies on Synthesis, Structure and Biological Activities of Novel Triazole Compounds Containing Thioamide

XU Liang-Zhong*, LI Wei-Hua, LI Kai, QIN Yong-Qi, LI Chun-Li,
HOU Bao-Rong   

  1. (1 College of Chemistry and Molecule Engineering, Qingdao University of Science and Tech-nology, Qingdao 266042)
    (2 College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266033)
    (3 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071)
  • Received:2005-01-14 Revised:2005-06-20 Published:2005-11-30
  • Contact: XU Liang-Zhong

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1966

被引次数

21

以三唑、芳香基苯乙酮和异硫氰酸苯酯为原料合成了4个含硫代酰胺的芳香三唑类化合物, 对四个化合物进行了IR, EA, 1H NMR和MS谱学表征. 培养了1-[1-苯胺硫化碳-1-(4-氟苯甲酰基)甲基]-1,2,4-三唑的单晶. 同时对这四个化合物进行了初步的生物活性测试, 结果表明它们具有一定的杀菌活性.

关键词: 合成, 1,2,4-三唑, 生物活性, 硫代酰胺, 晶体结构

Four novel triazole compounds containing thioamide group were designed and synthesized by using triazole, phenyl isothiocyanate and aryl ethyl ketone as raw material. Their structures were conformed by elemental analysis, 1H NMR, IR and MS spectra. The crystal structure of 1-[1-anilinothiocar-bonyl-1-(4-fluorobenzoyl)methyl]-1,2,4-trizole has been determined by X-ray diffraction analysis. The preliminary bioassays have shown that the title compounds exhibit certain antifungal activity.

Key words: 1,2,4-triazole, thioamide, synthesis, biological activitity, crystal structure