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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (03): 432-435. 上一篇    下一篇

研究论文

6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性研究

杨祖幸a，陈华a，毕英佐b，邹燕a，侯太平c，王玉良*,a   

  1. (a四川大学化学学院 成都 610064)
    (b华南农业大学动物科学院 广州 510642)
    (c四川大学生命科学学院 成都 610064)
  • 收稿日期:2007-02-22 修回日期:2007-08-20 发布日期:2008-03-18
  • 通讯作者: 王玉良

Synthesis and Anticoccidial Activity of Ethyl 6-(Substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylate

YANG Zu-Xinga,CHEN Huaa,BI Ying-Zuob ZOU Yana
HOU Tai-Pingc,WANG Yu-Liang*,a   

  1. (a College of Chemistry, Sichuan University, Chengdu 610064)
    (b College of Animal Science, South China Agricultural University, Guangzhou 510642)
    (c College of Life Science, Sichuan University, Chengdu 610064)
  • Received:2007-02-22 Revised:2007-08-20 Published:2008-03-18
  • Contact: WANG Yu-Liang

PDF

911

被引次数

15

设计并合成了10个新的6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯类化合物; 合成路线短, 产率高, 原料易得, 易实现工业化; 所有化合物的结构均经1H NMR, MS, IR和元素分析所证实; 并选择了其中7个化合物进行抗球虫活性实验, 结果表明: 其中4个6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯化合物具有抗球虫效果, 并有可能作为抗球虫药物使用.

关键词: 6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯, 合成, 抗球虫活性

Ten ethyl 6-(substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylates have been designed and synthesized. The new process has the advantages of high yield and cheap raw materials, which, thus, is convenient for the commercial production. Structures of the new compounds have been confirmed by 1H NMR, MS, IR spectra and elemental analysis. Seven of the new compounds were chosen for the anticoccidial activity test and the result has shown that four of them have anticoccidial activity.

Key words: synthesis, anticoccidial activity, ethyl 6-(substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylate