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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (03): 443-448. 上一篇    下一篇

研究论文

2,2-二甲基-5-取代苯基-3-(1,2,4-三唑-1/4-甲基)-3-戊醇类化合物的合成、表征及生物活性

王宇a,b，胡艾希*,a， 曹高a，李国希a，张建宇a,b
夏林a，欧晓明b，徐建兵b   

  1. (a湖南大学化学化工学院 长沙 410082)
    (b国家农药创制工程技术研究中心 长沙 410007)
  • 收稿日期:2007-03-06 修回日期:2007-07-10 发布日期:2008-03-18
  • 通讯作者: 胡艾希

Synthesis, Structure and Biological Activity of 2,2-Dimethyl- 5-(substituted phenyl)-3-(1,2,4-triazol-1/4-ylmethyl)pentan-3-ol

WANG Yua,b,HU Ai-Xi*,a, CAO Gaoa,LI Guo-Xia,ZHANG Jian-Yua,b
XIA Lina,OU Xiao-Mingb,XU Jian-Bingb   

  1. (a College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082)
    (b National Engineering Research Center for Agrochemicals, Changsha 410007)
  • Received:2007-03-06 Revised:2007-07-10 Published:2008-03-18
  • Contact: HU Ai-Xi

PDF

1221

被引次数

26

取代苯甲醛经缩合、催化氢化、环氧化和开环反应合成了9种2,2-二甲基-5-取代苯基-3-(1,2,4-三唑-1-基甲基)-3-戊醇类化合物和2种2,2-二甲基-5-取代苯基-3-(1,2,4-三唑-4-基甲基)-3-戊醇类新化合物. 并对1,2,4-三唑-1-基衍生物和1,2,4-三唑-4-基衍生物的选择性合成进行了研究; 新化合物结构经质谱, 1H NMR, 元素分析等确证, 并用单晶X射线衍射测定了化合物1a的晶体结构. 生物活性测试结果表明, 部分化合物具有强杀菌活性.

关键词: 三唑, 合成, 生物活性, 晶体结构

Nine novel 2,2-dimethyl-5-(substituted phenyl)-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ols and two novel 2,2-dimethyl-5-(substitutedphenyl)-3-(1,2,4-triazol-4-ylmethyl)pentan-3-ols were synthesized by condensa-tion, hydrogenation, epoxidation and ring-opening reactions from substituted benzaldehydes. 1,2,4-Triazol-1-yl and 1,2,4-triazol-4-yl derivatives could be selectively synthesized under certain condi-tions. Their structures were clearly established by MS, 1H NMR spectra and elemental analy-sis. The crystal structure of compound 1a had been determined by X-ray diffraction analysis. The preliminary bioassays indicated that some compounds showed fungicidal activities.

Key words: synthesis, biological activity, triazole, crystal structure