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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (04): 746-749. 上一篇    下一篇

研究简报

无溶剂条件下合成2-[3-氧代-1,3-二(未)取代苯基丙基]-1,2,3,4-四氢萘-1-酮

荣良策*,a,b，韩红霞a，蒋虹b，李小跃a，姚昌盛a，屠树江a,b   

  1. (a徐州师范大学化学化工学院 徐州 221116)
    (b江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2007-06-20 修回日期:2007-10-10 发布日期:2008-04-17
  • 通讯作者: 荣良策

Synthesis of 2-{3-Oxo-1,3-di[(un)substituted phenyl]pro-pyl}-1,2,3,4-tetrahydronaphthalen-1-ones under Solvent-Free Condi-tion

RONG Liang-Ce*,a,b,HAN Hong-Xiaa,JIANG Hongb,LI Xiao-Yuea
YAO Chang-Shenga,TU Shu-Jianga,b   

  1. (a College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)
    (b Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou 221116)
  • Received:2007-06-20 Revised:2007-10-10 Published:2008-04-17
  • Contact: RONG Liang-Ce

PDF

1005

被引次数

24

以3,4-二氢-1-萘酮和查尔酮为原料, 在 K2CO3-NaOH 存在下, 无溶剂室温研磨反应, 方便地得到2-[3-氧代-1,3-二(未)取代苯基丙基]-1,2,3,4-四氢萘-1-酮. 该方法具有反应条件温和、操作简单和产率较高等优点, 并通过IR, 1H NMR, 元素分析确定了产物的结构, 3b晶体结构通过X衍射测定.

关键词: 1-四氢萘酮, 查尔酮, 无溶剂, 合成

The synthesis of 2-{3-oxo-1,3-di[(un)substituted phenyl]propyl}-1,2,3,4-tetrahydronaphthalen- 1-ones from chalcones and 1-tetralone was carried out in excellent yields in the presence of K2CO3-NaOH under a solvent-free condition at room temperature using a grinding method. This protocol has the advantages of mild reaction conditions, simple procedure and high yields. The structures of the products were characterized on the basis of IR, 1H NMR spectroscopic data, elemental analysis, and that of 3b was additionally confirmed by X-ray diffraction analysis.

Key words: chalcone, 1-tetralone, solvent-free, synthesis