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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (05): 865-869. 上一篇    下一篇

研究简报

N-取代芳酰氨基-5-氟代苯基-2-呋喃甲酰硫脲的合成与生物活性测定

薛思佳*，卞王东，柴安，吁松瑞   

  1. (上海师范大学生命与环境科学学院化学系 上海 200234)
  • 收稿日期:2007-10-09 修回日期:2007-10-30 发布日期:2008-05-20
  • 通讯作者: 薛思佳

Synthesis and Biological Activities of N-(Substitutedaroylamino)-5-(fluorophenyl)-2-furoyl Thioureas

XUE Si-Jia*,BIAN Wang-Dong,CHAI An,YU Song-Rui   

  1. (College of Life and Environment Science, Shanghai Normal University, Shanghai 200234)
  • Received:2007-10-09 Revised:2007-10-30 Published:2008-05-20
  • Contact: XUE Si-Jia

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从5-氟代苯基-2-呋喃甲酸出发, 经酰化、异硫氰酸酯化, 再与取代芳酰肼反应合成了20个未见文献报道的N-取代芳酰氨基-5-氟代苯基-2-呋喃甲酰硫脲. 目标产物的结构经IR, 1H NMR和元素分析测定确证. 初步生物活性测试表明, 部分化合物对棉花枯萎病、黄瓜灰霉病、苹果轮纹病和棉花炭疽病有较好的选择性杀菌活性; 部分目标化合物有较好的除草活性.

关键词: 取代芳酰肼, 5-氟代苯基-2-呋喃甲酰硫脲, 合成, 生物活性

Twenty new N-(substituted aroylamino)-5-(fluorophenyl)-2-furoyl thioureas were synthesized and their structures were determined by 1H NMR, IR spectra and elemental analysis. The preliminary biological activity tests show that some of these target compounds have good fungicidal activities and some have good herbicidal activities.

Key words: 5-(fluorophenyl)-2-furoyl thiourea, synthesis, biological activity, hydrazide