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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (08): 964-968. 上一篇    下一篇

研究论文

无溶剂条件下Yb(OTf)3催化的亚甲基化合物和醛的Knoevenagel反应

王利民*，盛佳，张亮，韩建伟，樊兆玉，田禾   

  1. (华东理工大学精细化工研究所 华东理工大学结构可控先进功能材料教育部重点实验室 上海 200237)
  • 收稿日期:2004-07-09 修回日期:2005-03-05 发布日期:2005-07-30
  • 通讯作者: 王利民

Yb(OTf)3 Catalyzed Knoevenagel Reaction of Me-thylene Compounds with Aldehydes under Solvent-free Condition

WANG Li-Min*,SHENG Jia,ZHANG Liang
HAN Jian-Wei,FAN Zhao-Yu,TIAN He   

  1. (Institute of Fine Chemicals, Laboratory for Advanced Materials, East China University of Science and Technology,
    Shanghai 200237)
  • Received:2004-07-09 Revised:2005-03-05 Published:2005-07-30
  • Contact: WANG Li-Min

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在Yb(OTf)3催化下, 不用任何溶剂, 将活泼亚甲基化合物和各类醛进行Knoevenagel反应, 得到相应的取代烯烃衍生物. 此法操作简便, 对环境友好, 具有很高的反应产率, 且副产物少; 此外, 催化剂能够在进行反复回收利用之后仍然保持很高的催化活性.

关键词: Yb(OTf)3, 醛, 无溶剂法, 活泼亚甲基化合物, Knoevenagel缩合反应

Yb(OTf)3 catalyzed efficiently Knoevenagel condensation of active methylene compounds with various aldehydes under solvent free condition was described as a method for preparation of substituted olefins. The process is operationally simple, environmentally benign and has excellent yield without any side reactions. Furthermore, the catalyst could be recovered conveniently and reused efficiently.

Key words: solvent-free, Knoevenagel condensation, aldehyde, active methylene compound, Yb(OTf)3