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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (12): 1587-1590. 上一篇    下一篇

研究简报

N-[5-(4-吡啶基)-1,3,4-噻二唑-2-基]-N'-芳酰基脲的合成与生物活性

宋新建，冯桂荣，陈传兵，张正文，汪焱钢*   

  1. (1华中师范大学化学学院 武汉 430079)
    (2湖北民族学院化学与环境工程学院 恩施 445000)
    (3唐山师范学院化学系 唐山 063000)
  • 收稿日期:2005-01-27 修回日期:2005-06-07 发布日期:2005-11-30
  • 通讯作者: 汪焱钢

Synthesis and Biological Activity of N-[5-(Pyrid-4-yl)- 1,3,4-thiadiazol-2-yl]-N'-aroylureas

SONG Xin-Jian, FENG Gui-Rong, CHEN Chuan-Bing,
ZHANG Zheng-Wen, WANG Yan-Gang*   

  1. (1 College of Chemistry, Central China Normal University, Wuhan 430079)
    (2 College of Chemistry and Environmental Engineering, Hubei Institute for Nation-alities, Enshi 445000)
    (3 Department of Chemistry, Tangshan Normal Univer-sity, Tangshan 063000)
  • Received:2005-01-27 Revised:2005-06-07 Published:2005-11-30
  • Contact: WANG Yan-Gang

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为了寻找高活性的含杂环的新农药, 通过2-氨基-5-(4-吡啶基)-1,3,4-噻二唑与芳酰基异氰酸酯反应, 合成了17种新的芳酰基脲, 采用红外光谱、核磁共振氢谱与元素分析证明了其结构. 初步的活性试验表明, 部分目标化合物具有良好的植物生长调节活性, 其中2c, 2e, 2f, 2i和2k具有较好的细胞分裂素活性.

关键词: 芳酰基脲, 细胞分裂素, 1,3,4-噻二唑, 合成, 植物生长调节剂

In order to find highly active pesticide of heterocyclic ring, seventeen new aroylureas have been synthesized by the reaction of 2-amino-5-(pyrid-4-yl)-1,3,4-thiadiazole with aroyl isocyanates. The structures of the title compounds were confirmed by IR, 1H NMR spectra and elemental analysis. The preliminarily biological activity tests showed that such title compounds have a good activity as plant growth regulator, and 2c, 2e, 2f, 2i and 2k have relatively good activity of cytokinin.

Key words: 1,3,4-thiadiazole, cytokinin, synthesis, plant growth regulator, aroylurea