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有机化学 ›› 1998, Vol. 18 ›› Issue (3): 253-258. 上一篇    下一篇

研究论文

2-芳胺基-5-[5'-氨基-1'-(4''-氯苯基)-1', 2', 3'-三唑-4'-基]---1, 3, 4-恶二唑的合成

董恒山;张自义;惠新平;权彬;杨世琰   

  1. 兰州大学化学系;兰州大学应用有机化学国家重点实验室;中国科学院兰州化学物理研究所
  • 发布日期:1998-06-25

Synthesis of 2-arylamino-5-[5'-amino-1'-(4''-chlorophenyl)-1', 2', 3'-triazol-4'-yl]-1, 3, 4-oxadiazole

DONG HENGSHAN;ZHANG ZIYI;HUI XINPING;QUAN BIN;YANG SHIYAN   

  • Published:1998-06-25

利用1-[5'-氨基-1'-(4''-氯苯基)-1', 2', 3'-三唑-4'-甲酰基]-4-芳基氨基硫脲在汞盐Hg(OAc)2-HOAc中加热缩合, 制得11种新的2-芳胺基-5-[5'-氨基-1'-(4''-氯苯基)-1', 2', 3'-三唑-4'-基]---1, 3, 4-恶二唑。所有化合物的结构经元素分析, IR、MS以及1H NMR确认。选择代表物作生测试验, 结果表明, 2b, 2k中MIC3.1mg/L时, 对大肠杆菌及金黄色葡萄球菌繁殖有明显抑制。

关键词: 三唑 P, 质子磁共振谱法, 汞化合物, 恶二唑 P, 缩合反应, 杂环化合物, 硫脲, 红外分光光度法, 质谱法, 元素分析

Cyclization of 1-[5'-amino-1'-(4''-chlorophenyl)-1', 2', 3'-triazol-4'-acyl]-4-arylthiosemicarbazides with mercuric acetate [eg. Hg(OAc)2-HOAc] under heating gave eleven new 2-arylamino-5-[5'-amino-1'-(4''-chlorophenyl)-1', 2', 3'-triazol-4'-yl]-1, 3, 4-oxadiazole 2a～k. 2a, 2k of the compounds were picked as typical compounds of antibacterial test and their results showed the effective restraints from the multiply of Escherichia Coli, Staphylococcus aureus under MIC 3.1mg/L.

Key words: PYRRODIAZOLE P, MERCURY COMPOUNDS, PROTON MAGNETIC RESONANCE SPECTROMETRY, INFRARED SPECTROPHOTOMETRY, OXDIAZOLE P, THIOUREAS, HETEROCYCLIC COMPOUNDS, ELEMENTAL ANALYSIS, MASS SPECTROGRAPHY, CONDENSATION REACTION

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