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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (11): 1457-1462.    下一篇

综述与进展

亚乙烯基嘌呤核苷衍生物的合成、荧光和生化性质的研究进展

吴春辉，周杰*，陈长宝   

  1. (山东农业大学化学与材料科学学院 泰安 271018)
  • 收稿日期:2005-10-02 修回日期:2006-01-01 发布日期:2006-10-27
  • 通讯作者: 周杰

Progress in Synthesis, Fluorescent and Biochemical Properties of Etheno-substituted Purine Nucleoside Derivatives

WU Chun-Hui,ZHOU Jie*,CHEN Chang-Bao   

  1. (College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018)
  • Received:2005-10-02 Revised:2006-01-01 Published:2006-10-27
  • Contact: ZHOU Jie

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1163

被引次数

4

综述了亚乙烯基核苷衍生物(1,N6-亚乙烯基腺苷, N2,3-亚乙烯基腺苷, 1,N2-亚乙烯基鸟苷, N2,3-亚乙烯基鸟苷, 1,N6-亚乙烯基脱氧腺苷, 1,N2-亚乙烯基-2'-脱氧鸟苷, N2,3-亚乙烯基-2'-脱氧鸟苷)的研究进展, 讨论了其荧光性质和生物活性的应用, 展望了新型荧光扩环核苷衍生物的合成及其在荧光探针和高效药物筛选方面的研究前景.

关键词: 亚乙烯基核苷, 综述, 合成, 生化性质, 荧光

The development of etheno-nucleoside derivatives, including 1,N6-ethenoadenosine, N2,3-etheno- adenosine, 1,N2-ethenoguanosine, N2,3-ethenoguanosine, 1,N6-etheno-deoxyadenosine, 1,N2-etheno-2'- deoxyguanosine and N2,3-etheno-2'-deoxyguanosine is reviewed. Their fluorescent and biochemical properties are discussed. The study prospects of synthesis of novel fluorescent ring expansion nucleoside derivatives and their application to fluorescent probes and high though-put screening for drug are suggested.

Key words: synthesis, review, fluorescence, biochemical property, ethenonucleoside