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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (08): 1140-1143. 上一篇    下一篇

研究简报

1,3-双[3-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑-6-基]丙烷类化合物的合成

李德江*,1，傅和青2   

  1. (1郧阳师范专科学校化学系 丹江口 442700)
    (2华南理工大学化工学院化工研究所 广州 510640)
  • 收稿日期:2006-01-06 修回日期:2006-05-29 发布日期:2006-07-26
  • 通讯作者: 李德江

Synthesis of 1,3-Bis[3-aryl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole-6-yl]propanes

LI De-Jiang*,1,FU He-Qing2   

  1. (1 Department of Chemistry, Yunyang Teachers College, Danjiangkou 442700)
    (2 Research Institute of Chemical Engineering, South China University of Technol-ogy, Guangzhou 510640)
  • Received:2006-01-06 Revised:2006-05-29 Published:2006-07-26
  • Contact: LI De-Jiang

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戊二酸(1)与3-芳基-4-氨基-5-巯基-1,2,4-三唑(2a～2o)在相转移催化剂四丁基碘化铵和POCl3作用下, 高收率合成了一系列新的1,2-双[3-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑-6-基]丙烷(3a～3o). 其结构经IR, 1H NMR, MS和元素分析确证.

关键词: 相转移催化, 双-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑, 合成

A series of 1,3-bis[3-aryl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole-6-yl]propanes (3a～3o) were synthesized in good yields by condensation of pentanedioic acid (1) with 3-aryl-4-amino-5-mercapto-1,2,4-triazoles (2a～2o) in the presence of phase transfer catalyst tetrabutylammonium iodide and phosphorus oxychloride. The structures of 3a～3o were confirmed by IR, 1H NMR, MS spectra and elementary analyses.

Key words: bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole, synthesis, phase transfer catalysis