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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (06): 856-859. 上一篇    下一篇

研究简报

苯基(三甲基硅基亚甲基)锡二芳香酸酯的合成、结构和抗癌活性

林森*,1,2，付志飞1，何小立1,2，刘环宇1，孙小强2,3
汪信2，陆路德2   

  1. (1南昌大学化学系 南昌 330047)
    (2南京理工大学化工学院 南京 210094)
    (3江苏工业学院 常州 213016)
  • 收稿日期:2005-09-21 修回日期:2005-12-22 发布日期:2006-05-31
  • 通讯作者: 林森

Synthesis, Structure and Antitumour Activity of Phenyl-(trimethylsilylmethyl)tin Arylcarboxylates

LIN Sen*,1,2,FU Zhi-Fei1,HE Xiao-Li1,2,LIU Huan-Yu1,SUN Xiao-Qiang2,3
WANG Xin2,LU Lu-De2   

  1. (1 Department of Chemistry, Nanchang University, Nanchang 330047)
    (2 School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094)
    (3 Jiangsu Polytechnic University, Changzhou 213016)
  • Received:2005-09-21 Revised:2005-12-22 Published:2006-05-31
  • Contact: LIN Sen

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采用苯基(三甲基硅基亚甲基)二溴化锡和芳香酸在三乙胺存在下, 以1︰2的物质的量比进行反应, 合成了10个新的含硅混合二烃基锡化合物苯基(三甲基硅基亚甲基)锡二芳香酸酯. 利用IR, 1H NMR, 13C NMR和元素分析对它们的组成和结构进行了表征; 部分化合物的生物活性测定结果表明, 它们对某些癌细胞有较好的体外抗癌活性.

关键词: 合成, 结构, 抗癌活性, 混合二烃基锡化合物

Ten phenyl-(trimethylsilylmethyl)tin arylcarboxylates have been synthesized by the reaction of phenyl-(trimethylsilylmethyl)tin dibromide with arylcarboxylic acids. Their structures were characterized by elemental analysis, IR, 1H NMR and 13C NMR spectra. The preliminary bioassay tests showed that they had a good antitumour activity in vitro against Hela and SPC-A-1 tumour cells.

Key words: structure, antitumour activity, synthesis, mixed diorganotin compound