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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (06): 852-855. 上一篇    下一篇

研究简报

苯并吡喃[3,4-c]吡啶-5-酮类化合物的合成

李谷才*，尹端沚，沈玉梅，汪勇先   

  1. (中国科学院上海应用物理研究所 放射性药物研究中心 上海 201800)
  • 收稿日期:2005-04-13 修回日期:2005-12-16 发布日期:2006-05-31
  • 通讯作者: 李谷才

Synthesis of Chromeno[3,4-c]pyridin-5-ones

LI Gu-Cai*,YIN Duan-Zhi,SHEN Yu-Mei,WANG Yong-Xian   

  1. (Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics,
    Chinese Academy of Sciences, Shanghai 201800)
  • Received:2005-04-13 Revised:2005-12-16 Published:2006-05-31
  • Contact: LI Gu-Cai

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以4-酮-3-甲酸甲酯哌啶盐酸盐为原料, 通过分子间环加成和N-烷基化反应, 合成了一系列潜在的多巴胺D4受体配基苯并吡喃[3,4-c]吡啶-5-酮类化合物, 并用1H NMR, IR, ESI-MS, 元素分析对其进行了表征.

关键词: 苯并吡喃[3,4-c]吡啶-5-酮, 多巴胺D4受体, 合成, 表征

A series of novel chromeno[3,4-c]pyridin-5-ones as potential dopamine D4 receptor ligands were prepared from proper phenols and methyl-4-oxo-3-piperidine carboxylate hydrochloride through intermolecular cycloaddition and N-alkylation reaction. Their structures were confirmed by elemental analysis, IR, 1H NMR and ESI-MS spectra.

Key words: dopamine D4 receptor, chromeno[3,4-c]pyridin-5-one, synthesis, characterization