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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (08): 987-990. 上一篇    下一篇

研究简报

微波促进下6-氨基-4-芳基-5-氰基-3-甲基-1-苯基吡啶[2,3-c]并吡唑的合成

朱松磊，屠树江*，李团结，章晓镜，纪顺俊*，张勇   

  1. (1徐州师范大学化学系 徐州 221116 )
    (2徐州医学院化学系 徐州 221002)
    (3苏州大学化学化工学院 苏州 215006)
  • 收稿日期:2004-10-29 修回日期:2005-02-01 发布日期:2005-07-30
  • 通讯作者: 屠树江, 纪顺俊

Synthesis of 6-Amino-4-aryl-5-cyano-3-methyl-1-phenylpyridino- [2,3-c]pyrazole under Microwave Irradiation

ZHU Song-Lei,TU Shu-Jiang*,LI Tuan-Jie,ZHANG Xiao-Jing
JI Shun-Jun*,ZHANG Yong   

  1. (1 Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
    (2 Department of Chemistry, Xuzhou Medical College, Xuzhou 221002)
    (3 College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006)
  • Received:2004-10-29 Revised:2005-02-01 Published:2005-07-30
  • Contact: TU Shu-Jiang, JI Shun-Jun

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5-氨基-3-甲基-1-苯基吡唑与芳亚甲基丙二腈在少量乙二醇中, 经微波辐射得到6-氨基-4-芳基-5-氰基-3-甲基-1-苯基吡啶[2,3-c]并吡唑衍生物, 反应4～8 min完成, 产率为71%～90%, 产物结构通过红外、核磁共振、元素分析及单晶X射线分析表征.

关键词: 吡啶[2,3-c]并吡唑, 微波, 晶体结构

A series of 6-amino-4-aryl-5-cyano-3-methyl-1-phenylpyridino[2,3-c]pyrazole derivatives were synthesized by the reaction of 5-amino-3-methyl-1-phenylpyrazole with arylidene derivatives of malononitrile under microwave irradiation. The reaction was completed in 4～8 min with 71%～90% yields. All the products were characterized by IR, 1H NMR spectra and elemental analysis. 3j was determined by the X-ray diffraction.

Key words: crystal structure, microwave, pyridino[2,3-c]pyrazole