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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (04): 442-444. 上一篇    下一篇

研究简报

3-巯基-5-芳香基-4-芳基亚甲胺基-4H-1,2,4-三唑的合成及波谱研究

张安将*，张力学，丁金昌   

  1. (温州师范学院药物研究所 温州 325027)
  • 收稿日期:2004-02-27 修回日期:2004-10-12 发布日期:2005-03-30
  • 通讯作者: 张安将

Synthesis and NMR Study of 4-(Arylmethylidene)-amino-5-aryl-3- mercapto-4H-1,2,4-triazoles

ZHANG An-Jiang*,ZHANG Li-Xue,DING Jin-Chang   

  1. (Institute of Pharmacy, Wenzhou Normal College, Wenzhou 325027)
  • Received:2004-02-27 Revised:2004-10-12 Published:2005-03-30
  • Contact: ZHANG An-Jiang

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5-取代-4-氨基-3-巯基-1,2,4-三唑与芳香醛在弱酸性乙醇溶液中反应, 合成了一系列3-巯基-5-芳香基-4-芳基亚甲胺基-4H-1,2,4-三唑(3a～3d)及水溶性的3-巯基-5-(D-葡萄糖-1-基)-4-(4-氯代苯基)亚甲胺基-4H-1,2,4-三唑(3e)新化合物. 以元素分析, IR, NMR, MS实验技术对其结构进行了表征, 并研究其NMR波谱特征.

关键词: 3-巯基-5-芳香基-4-芳基亚甲胺基-4H-1,2,4-三唑, 3-巯基-5-(D-葡萄糖-1-基)-4-(4-氯代苯基)亚甲胺基-4H-1,2,4-三唑, 合成, NMR

4-(Arylmethylidene)amino-5-aryl-3-mercapto-4H-1,2,4-triazoles (3a～3d) and 4-(4-chloroph- enyl-methylidene)amino-5-(D-gluco-pentitol-1-yl)-3-mercapto-4H-1,2,4-triazole (3e) were synthesized in good yields by reaction of 4-amino-3-mercapto-5-substituent-1,2,4-triazole with aryl aldehyde in ethanolic medium. Their structures were confirmed by elemental analysis, IR, NMR, MS spectra and the characteristics of NMR spectra were also discussed.

Key words: synthesis, NMR, 4-(4-chlorophenylmethylide- ne)amino-5-(D-gluco-pentitol-1-yl)-3-mercapto-4H-1,2,4-triazole, 4-(arylmethylidene)amino-5-aryl-3-mercapto-4H-1,2,4-triazole