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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (07): 1199-1203. 上一篇    下一篇

研究论文

1,3,4-均三唑并[2,1-b]-1,3,4-噻二唑衍生物的合成及生物活性

柴 安; 薛思佳*; 卞王东 ; 吁松瑞   

  1. (上海师范大学化学系 上海 200234)
  • 收稿日期:2007-11-13 修回日期:2007-12-24 发布日期:2008-07-28
  • 通讯作者: 薛思佳

Synthesis and Biological Activity of 1,3,4-Triazolo[2,1-b]- 1,3,4-thiadiazole Derivatives

CHAI, An; XUE, Si-Jia*; BIAN, Wang-Dong ; YU, Song-Rui   

  1. (Department of Chemistry, Shanghai Normal University, Shanghai 200234)
  • Received:2007-11-13 Revised:2007-12-24 Published:2008-07-28
  • Contact: XUE, Si-Jia

PDF

672

被引次数

33

以5-对甲苯基-1-氨基-2-巯基-1,3,4-均三唑和取代苯氧乙酰异硫氰酸酯为原料, 合成了10个未见文献报道的5-对甲苯基-2-取代苯氧乙酰氨基均三唑并[2,1-b]-1,3,4-噻二唑类化合物, 通过元素分析, 1H NMR, IR和MS确定化合物的结构, 初步生物活性测试表明目标化合物具有较好的除草活性.

关键词: 均三唑并[2,1-b]-1,3,4-噻二唑, 合成, 除草活性

Ten unreported compounds 5-(p-tolyl)-2-(substituted phenoxyacetamido)-s-triazolo[2,1-b]- 1,3,4-thiadiazoles were synthesized by the reaction of 5-(p-tolyl)-1-amino-2-mercapto-1,3,4-triazole with substituted phenoxyacetyl isothiocyanates, their structures were elucidated and confirmed by elemental analysis, IR, 1H NMR and MS spectra, and preliminary biological test indicated that the compounds had good herbicidal activities.

Key words: synthesis, herbicidal activity, s-triazolo[2,1-b]-1,3,4-thiadiazole