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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (01): 132-136. 上一篇    下一篇

研究简报

1,3,4-噻二唑基芳酰基脲的合成和生物活性

韩 锋，万 嵘*，王 瑶，王 朋，王锦堂   

  1. (南京工业大学理学院 南京 210009)
  • 收稿日期:2009-03-25 修回日期:2009-07-19 发布日期:2010-01-20
  • 通讯作者: 万嵘 E-mail:rwan@njut.edu.cn
  • 基金资助:

    2007年度江苏省高技术研究计划(农业) (NO.BG2007329)和南京工业大学博士创新基金(NO.BSCX200717)

Synthesis and Biological Activity of 1,3,4-Thiadiazole Aroylurea Derivatives

Han,Feng，Wan,Rong*，Wang,Yao，Wang,Peng，Wang,Jintang   

  1. (Department of Applied Chemistry，Nanjing University of Technology，Nanjing 210009)
  • Received:2009-03-25 Revised:2009-07-19 Published:2010-01-20

PDF

1800

被引次数

28

以2-氨基-5-取代苯基-1,3,4噻二唑和2,6-二氟苯甲酰异氰酸酯为起始原料，合成了10个未见文献报道的含1,3,4-噻二唑环的芳酰基脲类衍生物。通过1H NMR，IR，ESI-MS和元素分析确定化合物的结构。初步生物活性测试表明，此类化合物具有一定的杀虫活性，其中化合物3d (3,5-(CH3)2)和3g (4-C4H9)对蚕豆蚜的杀虫死亡率达到90%以上.

关键词: 1,3,4-噻二唑, 芳酰基脲, 合成, 生物活性

Ten novel benzoyl ureas containing a 1,3,4-thiadiazole group were synthesized by the reaction of 2-amino-5-substituted phenyl-1,3,4-thiadiazole and 2,6-difluorobenzoyl isocyanate，and structurally con-firmed by 1H NMR，IR，ESI-MS techniques and elemental analysis。Preliminary bioassay test indicated that some compounds showed insecticidal activity。Compounds 3d (3,5-(CH3)2) and 3g (4-C4H9) exhibit good insecticidal activity against Aphis craccivora with higer than 90% mortality.

Key words: 1,3,4-thiadiazole, aroyl urea, synthesis, biological activity