SIOC English
有机化学
高级检索

有机化学 ›› 2009, Vol. 29 ›› Issue (12): 2026-2029. 上一篇    下一篇

研究简报

O,O-二乙基-N-[2-(3-乙酰基-2,2-二甲基-环丁基)-乙酰] 硫代磷酰胺合成及杀虫活性研究

赵文浩a,b；梁宏艳a；陈海燕a；周 红a；林翠梧*,a   

  1. (a广西大学化学化工学院 南宁 530004)
     (b广西化工研究院 南宁 530001)
  • 收稿日期:2009-03-21 修回日期:2009-05-25 发布日期:2009-07-24
  • 通讯作者: 林翠梧 E-mail:lincuiwu@gxu.edu.cn
  • 基金资助:

    广西科技攻关项目

Synthesis of O,O-Diethyl-N-[2-(3-acetyl-2,2-dimethyl-cyclobutyl)- aceto]thiophosphoramidate and Its Insecticidal Activity

Zhao, Wenhao a,b；Liang, Hongyan a；Chen, Haiyana；Zhou, Honga；Lin, Cuiwu*,a   

  1. (a College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004) (b Guangxi Research Institute of Chemical Industry, Nanning 530001)
  • Received:2009-03-21 Revised:2009-05-25 Published:2009-07-24
  • Contact: Lin Cui-Wu E-mail:lincuiwu@gxu.edu.cn

PDF

1342

被引次数

6

α-蒎烯经过氧化、酰氯化制成蒎酮酰氯, 再与二乙基硫代膦酰胺反应, 合成了未见报道的标题化合物7, 经IR, MS, 1H NMR, 13C NMR等对标题化合物的结构进行了表征. 测试了标题化合物对甘蓝薄翅螟的毒力及其对敌百虫的增效作用. 初步生物活性测试结果表明, 标题化合物与敌百虫混合对甘蓝薄翅螟有明显的增效作用, 当标题化合物与敌百虫以3∶7的比例混合其增效作用最显著, 共毒系数(co-toxicity oefficient, CTC)为226.

关键词: α-蒎烯, 蒎酮酸, 硫代膦酰胺, 合成, 杀虫活性

The title compound, O,O-diethyl-N-[2-(3-acetyl-2,2-dimethyl-cyclobutyl)-aceto]thiophosphor- amidate 7 is a new compound, which was synthesized by the reaction of α-pinene, and structurally confirmed by IR, MS, 1H NMR, and 13C NMR techniques. The synergistic activity of the mixture of the title compound and trichlorfon to Crocidolomia pavonana (Fabricius) was evaluated by the method of co-toxicity coefficient (CTC). The primarily bioassay result showed that the mixtures of the title compound and trichlorfon had sig-nificant synergism to Crocidolomia pavonana (Fabricius), and the CTC of the mixture (3∶7) of the title compound and trichlorfon reached 226.

Key words: α-pinene, pinonic acid, thiophosphoryl amide, synthesis, insecticidal activity