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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (02): 303-306. 上一篇    下一篇

研究简报

二吡唑基甲酮类化合物的合成和表征

李艳，邵腾飞，战付旭，孟庆洋，贾炯，王建武*   

  1. (山东大学化学与化工学院 济南 250100)
  • 收稿日期:2009-02-05 修回日期:2009-07-03 发布日期:2010-02-20
  • 通讯作者: 王建武 E-mail:jwwang@sdu.edu.cn
  • 基金资助:

    国家级.国家自然科学基金

Synthesis and Characterization of Dipyrazolylmethanones

Li Yan Shao Tengfei Zhan Fuxu Meng Qingyang Jia Jiong Wang Jianwu*   

  1. (School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100)
  • Received:2009-02-05 Revised:2009-07-03 Published:2010-02-20

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以5-氨基-3-甲硫基-1H-吡唑-4-羧酸乙酯(1)为原料, 依次经肼解、与取代的乙烯酮二硫缩醛缩合和烷基化合成了一系列二吡唑基甲酮类化合物, 经1H NMR, 13C NMR和元素分析确证了它们的结构, 部分化合物进一步经过了质谱表征.

关键词: 吡唑, 二吡唑基甲酮, 乙烯酮二硫代缩醛, 合成

A series of dipyrazolylmethanones were synthesized via the hydrazinolysis of ethyl 5-amino-3- methylthio-1H-pyrazole-4-carboxylate (1), followed by the condensation with substituted ketene dithioacetals and sequent alkylation. These compounds were characterized by 1H NMR, 13C NMR spectra and elemental analyses, and part of them were further characterized by IR and MS techniques.

Key words: pyrazole, dipyrazolylmethanone, ketene dithioacetal, synthesis