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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (02): 295-298. 上一篇    下一篇

研究简报

温和条件下对甲基苯磺酸铝高效催化一锅法合成β-氨基酮衍生物

王敏*,1，梁艳1，宋志国2，姜恒3   

  1. (1渤海大学化学化工学院 锦州 121000)
    (2渤海大学科技实验中心 锦州 121000)
    (3辽宁石油化工大学石油化工学院 抚顺 113001)
  • 收稿日期:2009-05-05 修回日期:2009-07-09 发布日期:2010-02-20
  • 通讯作者: 王敏 E-mail:minwangszg@yahoo.com.cn

Efficient One-Pot Synthesis of β-Amino Ketone Derivatives Catalyzed by Aluminium p-Toluenesulfonate under Mild Conditions

Wang Min*,1 Liang Yan1 Song Zhiguo2 Jiang Heng3   

  1. (1 College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121000)
    (2 Center for Science & Technology Experiment, Bohai University, Jinzhou 121000)
    (3 College of Petrochemical Engineering, Liaoning Shihua University, Fushun 113001)
  • Received:2009-05-05 Revised:2009-07-09 Published:2010-02-20

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室温条件下, 对甲基苯磺酸铝可有效催化芳香酮、芳香醛和芳香胺的Mannich反应, 三组分“一锅法”合成了一系列β-氨基酮衍生物. 考察了溶剂及反应条件对产率的影响. 反应结束后, 催化剂经简单相分离可回收并多次重复使用, 催化活性无明显下降. 产物结构经IR, 1H NMR, 元素分析进行表征.

关键词: 对甲基苯磺酸铝, Mannich反应, β-氨基酮衍生物, 一锅法, 芳香醛

The three-component one-pot Mannich reaction of aromatic ketones, aromatic aldehydes and aromatic amines catalyzed by aluminium p-toluenesulfonate afforded the corresponding β-amino ketone derivatives efficiently at room temperature. The effects of different solvents and reaction conditions on the yields were investigated. After reaction, the catalyst could be easily recovered by phase separation and reused for many times without distinct decrease in its catalytic activity. The structures of products were characterized by IR, 1H NMR spectra and elemental analysis.

Key words: aluminium p-toluenesulfonate, Mannich reaction, β-amino ketone derivative, one-pot synthe-sis, aromatic aldehyde