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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (06): 860-864. 上一篇    下一篇

研究论文

N-(末端三甲基硅苄基甘氨酸肽链)邻苯二甲酰亚胺的光诱导单电子转移成环反应

金英学*，谭广慧，赵俊明，张鹏，王丙南，郑鹏   

  1. 哈尔滨师范大学化学化工学院 哈尔滨 150025
  • 收稿日期:2009-08-28 修回日期:2009-11-19 发布日期:2010-01-15
  • 通讯作者: 金英学 E-mail:yenghak@hrbnu.edu.cn

Photoinduced Single Electron Transfer Cyclization Reactions of N-(Amidosilane terminated polybenzylglycine peptide chain)phthalimide

JIN Ying-Xue, TAN Guang-Hui, ZHAO Jun-Ming, ZHANG Peng, WANG Bing-nan, ZHENG Peng   

  1. College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025
  • Received:2009-08-28 Revised:2009-11-19 Published:2010-01-15

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以苄基甘氨酸为起始原料合成N-(末端三甲基硅苄基甘氨酸肽链)邻苯二甲酰亚胺(1). 1在甲醇溶剂中光照发生单电子转移反应, 生成分子内双自由基10, 自由基偶合生成环聚甘氨酸肽化合物2. 此反应产率好, 区域选择性高. 所有新化合物结构均经NMR和质谱验证.

关键词: 光诱导, 单电子转移, 环肽化合物, 合成

Benzylglycine was used as starting material for the synthesis of N-(amidosilane teminated polybenzylglycine peptide chain)phthalimide (1). Irradiating methanol solution containing 1 is observed to promote formation of biradical 10. Then the biradical 10 copulates to give cyclopolyglypeptides 2 in high yield and high selectivity. The structures of all the new compounds were characterized by MS and NMR techniques.

Key words: photoinduced, single electro transfer, cyclic peptide compound, synthesis