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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (07): 1032-1038. 上一篇    下一篇

研究论文

2,2 -二取代双[3-芳基喹唑啉-4(3H)-酮]的合成

杨绪红1，吴鸣虎*1，丁明武2   

  1. (1咸宁学院化学与生命科学学院 咸宁 437100)
    (2华中师范大学农药与化学生物学教育部重点实验室 武汉 430079)
  • 收稿日期:2009-07-28 修回日期:2009-11-27 发布日期:2010-02-23
  • 通讯作者: 吴鸣虎 E-mail:minghuwu@hotmail.com
  • 基金资助:

    No. 20772041;国家级.国家自然科学基金

Synthesis of 2,2 -Disubstituted Bis(3-arylquinazolin-4(3H)-one)s

Yang Xuhong1 Wu Minghu*1 Ding Mingwu2   

  1. (1Faculty of Chemistry and Life Science, Xianning College, Xianning 437100) (2Key Laboratory of Pesticide & Biology, Ministry of Education, Central China Normal University, Wuhan 430079)
  • Received:2009-07-28 Revised:2009-11-27 Published:2010-02-23
  • Contact: Wu Ming-Hu E-mail:minghuwu@hotmail.com

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研究了多米诺骨牌反应合成2,2 -二取代双[3-芳基喹唑啉-4(3H)-酮]衍生物的方法. 该方法应用膦亚胺与芳基异氰酸酯的氮杂Wittig反应得到碳二亚胺, 接着与二酚在碳酸钾存在下反应, 合成了28个未见文献报道的双喹唑啉酮衍生物. 所得产物的结构经IR, H NMR, MS和元素分析测定, 并且采用X射线衍射分析方法进一步确证了化合物的结构.

关键词: 喹唑啉-4(3H)-酮, 膦亚胺, 碳二亚胺, 二酚, 氮杂Wittig反应, 合成

Twenty eight 2,2 -disubstituted bis(3-arylquinazolin-4(3H)-one)s () were synthesized by domino reaction of iminophosphorane with aromatic isocynates to give carbodiimides and subsequent reaction of with diphenols in the presence of potassium carbonate. The structures of were confirmed by IR, H NMR, MS techniques and elemental analysis, and the structure of was further determined by X-ray single crystal diffraction.

Key words: quinazolin-4(3H)-one, iminophosphorane, carbodiimide, diphenol, domino reaction, synthesis

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