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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (9): 1342-1346. 上一篇    下一篇

研究论文

新型含吡唑基异噁唑衍生物的合成与表征

周英雷，沈松伟，刘方明   

  1. (杭州师范大学材料与化学化工学院 杭州 310036)
  • 收稿日期:2009-12-11 修回日期:2010-01-22 发布日期:2010-04-22
  • 通讯作者: 周英雷 E-mail:zhouyl993@163.com
  • 基金资助:

    新型含多氮杂环嘧啶-2-（硫）酮及其稠杂环衍生物的绿色合成，活性测试和构效关系研究

Synthesis and Configuration of Novel Isoxazole Derivatives Contain-ing Pyrazole Moiety

ZHOU Ying-Lei, SHEN Song-Wei, LIU Fang-Ming   

  1. (College of Materials and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036)
  • Received:2009-12-11 Revised:2010-01-22 Published:2010-04-22
  • Contact: ZHOU Ying-Lei E-mail:zhouyl993@163.com

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1249

被引次数

13 | 2

以查尔酮4和取代的α-氯代吡唑甲醛肟3为原料, 通过1,3-偶极环加成反应得到了16种新型的含吡唑基异噁唑衍生物, 方法简单可行. 化合物4,5-二氢-3-(1-苯基-3-甲基-5-取代-4-基)-5-芳基-4-芳酰基异噁唑啉(5)的结构经过IR, 1H NMR, MS及元素分析确证. 并利用单晶X射线衍射法测定了5g晶体结构.

关键词: 吡唑, 1,3-偶极环加成, 异噁唑, 晶体结构

Sixteen new isoxazole derivatives containing pyrazole moiety were synthesized simply and feasibly by chalcone 4 and substituted pyrazolohydroximinoyl chlorides 3 as stating materials through 1,3-dipolar cycloaddition reaction. The structures of 4,5-dihydro-3-(1-pnenyl-3-methyl-5-substituted-4-yl)- 5-aryl-4-aroylisoxazolines (5) were confirmed by IR, 1H NMR, MS techniques and elemental analysis. Compound 5g was subjected to X-ray single crystal diffraction analysis to determine crystallographic structure.

Key words: pyrazole, 1,3-dipolar cycloaddition, isoxazole, crystallographic structure