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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (02): 176-186. 上一篇    下一篇

综述与进展

克力托辛(Clitocine)及其类似物的合成与生物活性

郭翔海*,1，康宏2，郑岚曦2，姜申德*,2   

  1. (1天津大学化工学院 系统生物工程教育部重点实验室 天津 300072)
    (2天津大学药物科学与技术学院 天津 300072)
  • 收稿日期:2010-05-13 修回日期:2010-06-22 发布日期:2010-07-08
  • 通讯作者: 郭翔海 E-mail:guoxh@tju.edu.cn

Synthetic Methods and Biological Activities of Clitocine and Its Ana-logues

Guo Xianghai*,1 Kang Hong2 Zheng Lanxi2 Jiang Shende*,2   

  1. (1 Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072)
    (2 School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072)
  • Received:2010-05-13 Revised:2010-06-22 Published:2010-07-08

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克力托辛是一种从蘑菇Clitocybe inversa中分离出的天然核苷. 它及其类似物具有很高的生物活性. 综述了克力托辛及2 -脱氧克力托辛类似物、碱基修饰克力托辛类似物、5 -脱氧克力托辛类似物、碳环克力托辛类似物以及无环克力托辛类似物的合成方法, 并对克力托辛及其类似物在农业害虫杀灭、腺苷激酶抑制剂、抗肿瘤、抗病毒等药物研究中的应用进行了概述.

关键词: 克力托辛, 合成, 核苷类似物, 抗病毒, 抗肿瘤

Clitocine is a naturally occurring amino exocyclic nucleoside isolated from the mushroom Clitocybe inversa. It and its analogues have high bioactivities. In this review, the synthetic methods of clitocine, 2 -deoxy clitocine, aglycone-modified clitocine, 5 -deoxy clitocine, carbosugar clitocine and acyclic clitocine analogues are summarized. The application of clitocine and its analogues to study on insecticidal agent, adenosine kinase (AKase) inhibitor, antiviral and antitumor drugs is presented as well.

Key words: clitocine, synthesis, nucleoside analogue, antiviral, antitumor