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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (04): 582-585. 上一篇    下一篇

研究简报

N-吡啶(噻唑)甲氧苯基-N-芳酰基脲衍生物的合成与生物活性

梁英，张志刚，魏三，杨自文*   

  1. (湖北省农业科学院 湖北省生物农药工程研究中心 绿色化学与合成研究室 武汉 430064)
  • 收稿日期:2010-06-28 修回日期:2010-09-25 发布日期:2010-12-06
  • 通讯作者: 梁英 E-mail:ly.liang8@gmail.com

Synthesis and Biological Activities of N-Pyridyl(thiazolyl) Methyloxyphenyl-N-arylacyl Urea Derivatives

LIANG Ying, ZHANG Zhi-Gang, WEI San, YANG Zi-Wen   

  1. (Laboratory of Green Chemistry & Synthesis, Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Science, Wuhan 430064)
  • Received:2010-06-28 Revised:2010-09-25 Published:2010-12-06
  • Contact: LIANG Ying E-mail:ly.liang8@gmail.com

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通过芳酰基异氰酸酯与吡啶(噻唑)甲氧苯胺的亲核加成反应, 合成8个未见文献报道的N-吡啶(噻唑)甲氧苯基- N-芳酰基脲衍生物. 其结构经1H NMR, IR和元素分析表征. 初步生物活性试验表明, 标题化合物具有良好的杀虫活性, 如5d在100 mg/L浓度下, 对小菜蛾(Plutella xylostella)和棉铃虫(Heliothis armigera)具有100%的抑制活性.

关键词: 苯甲酰脲, 合成, 杀虫活性

Eight new N-pyridyl(thiazolyl) methyloxyphenyl-N-arylacyl urea derivatives were synthesized by the nucleophilic addition reaction of pyridyl(thiazolyl) methyloxy aniline with arylacyl isocyanates. Their structures were confirmed by 1H NMR, IR spectra and elemental analysis. Preliminary biological tests indicated that these compounds exhibited obvious insecticidal activity, especially, compound 5d showed 100% inhibitory activity against Heliothis armigera and Plutella xylostella at 100 mg/L.

Key words: benzoylurea, synthesis, insecticidal activity