关键词: 1,2,3-三唑, 噻唑, 腙, 合成, 生物活性

In order to find novel compounds with medical or agricultural bioactivity, 1-chlorophenyl-5- methyl-1,2,3-triazol-4-ethanonethiosemicarbazone was obtained from p-chlorophenylamine as starting materials by four-step reaction, followed by the reaction of intermediate 3 with ω-bromoacetophenone under reflux condition or ultrasonic irradiation to afford a series of N-(1-p-chlorophenyl-5-methyl-1,2,3-triazole-4- ace-tyl)-N-(4-aryl-thiazol-2-yl)-hydrazones. The structures of all compounds were characterized by ele-mental analysis, ¹H NMR and MS techniques. The results of preliminary bioactivity tests indi-cated that compounds 4d and 4e possess certain biological activities.

Key words: 1,2,3-triazole, thiazole, hydrazone, synthesis, bioactivity