有机化学 ›› 2011, Vol. 31 ›› Issue (05): 616-623. 上一篇    下一篇

综述与进展

基于2(5H)-呋喃酮的碳-杂成键反应研究进展

TAN Yue-He, LI Jian-Xiao, HONG Wen-Kun, WANG Chao-Yang   

  1. (华南师范大学 化学与环境学院 广州 510006)
  • 收稿日期:2010-07-15 修回日期:2010-09-11 发布日期:2010-11-27
  • 通讯作者: 汪朝阳 E-mail:wangwangzhaoyang@tom.com

Progress in the Formation of Carbon-Hetero Bond Based on 2(5H)-Furanones

TAN Yue-He, LI Jian-Xiao, HONG Wen-Kun, WANG Chao-Yang   

  1. (School of Chemistry and Environment, South China Normal University, Guangzhou 510006)
  • Received:2010-07-15 Revised:2010-09-11 Published:2010-11-27
  • Contact: Zhaoyang Wang E-mail:wangwangzhaoyang@tom.com

2(5H)-呋喃酮结构单元广泛存在于天然产物中, 同时许多2(5H)-呋喃酮类化合物也是重要的有机合成中间体. 因此, 基于常见2(5H)-呋喃酮(1)的有机合成研究近年来引起了人们的关注. 根据在有机合成反应中成键方式的不同, 综述了在2(5H)-呋喃酮(1)环上形成C—O, C—N, C—S, C—P, C—Se, C—Si等碳—杂键的反应研究进展.

关键词: 2(5H)-呋喃酮, 碳—杂键, Michael加成, 手性, 串联反应

Recently, the organic synthesis based on 2(5H)-furanones (1) has attracted much attention owing to the unique carbon skeleton of 2(5H)-furanone which is widely present in a variety of natural products and their utility as valuable synthetic intermediates. Classified as different bond kinds, the progress in the formation reactions of carbon-oxygen bond, carbon-nitrogen bond, carbon-sulfur bond, carbon-phosphorus bond, carbon-selenium bond and carbon-silicon bond on 2(5H)-furanone ring is reviewed.

Key words: 2(5H)-furanone, carbon-hetero bond, Michael addition, chirality, tandem reaction