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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (11): 1914-1916. 上一篇    下一篇

研究简报

1-肼基-2,3-二氮杂萘盐酸盐的合成新方法

赵宝海，林吉茂*   

  1. (山东大学化学与化工学院 济南 250100)
  • 收稿日期:2011-04-21 修回日期:2011-05-31 发布日期:2011-06-29
  • 通讯作者: 赵宝海 E-mail:zhaobaohai0136@163.com

A Novel Synthetic Method of 1-Hydrazinophthalazine Hydrochloride

ZHAO Bao-Hai, LIN Ji-Mao   

  1. (School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100)
  • Received:2011-04-21 Revised:2011-05-31 Published:2011-06-29

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研究了1-肼基-2,3-二氮杂萘盐酸盐的合成新方法. 以相对廉价易得的邻苯二甲酸酐为起始原料, 依次通过还原、溴代、环合、取代、酸化等反应步骤得到目标产物1-肼基-2,3-二氮杂萘盐酸盐. 研究表明该方法具有原料便宜易得、收率高、产物易分离纯化、后处理操作简单、总成本低等优点.

关键词: 邻苯二甲酸酐, 1-肼基-2,3-二氮杂萘盐酸盐, 合成

In this paper, a novel synthetic method of 1-hydrazinophthalazine hydrochloride was reported starting from cheap and easily accessible phthalic anhydride. The 1-hydrazinophthalazine hydrochloride could be obtained by reduction, bromination, cyclization, substitution and acidification separately. The results showed that the advantages of this method were simply available starting materials, relatively high yield, easily purification of the product and low cost.

Key words: phthalic anhydride, 1-hydrazinophthalazine hydrochloride, synthesis