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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (11): 1939-1942. 上一篇    下一篇

研究简报

1,3-二取代-2-硫代咪唑啉酮的合成

王璐1，潘向强2，饶卫东2，邹建平*2   

  1. (1苏州大学分析测试中心 苏州 215123)
    (2苏州大学材料与化学化工学部 江苏省有机合成重点实验室 苏州 215123)
  • 收稿日期:2011-05-14 修回日期:2011-07-16 发布日期:2011-08-26
  • 通讯作者: 邹建平 E-mail:jpzou@suda.edu.cn

Synthesis of 1,3-Disubstituted-2-thioxo-4-imidazolidinones

Wang Lu1 Pan Xiangqiang2 Rao Wei-dong2 Zou Jianping*2   

  1. (1 Testing and Analysis Center, Suzhou University, Suzhou 215123)
    (2 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemis-try, Chemical Engineering and Material Science, Suzhou University, Suzhou 215123)
  • Received:2011-05-14 Revised:2011-07-16 Published:2011-08-26

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被引次数

2

1-苯甲酰基-3-芳基硫脲与氯乙酰氯反应合成了1-芳基-3-苯甲酰基-2-硫代咪唑啉-4-酮, 与二氯乙酰氯反应合成了1-芳基-3-苯甲酰基-5-氯-2-硫代咪唑啉-4-酮, 与三氯乙酰氯反应时仅得到了硫脲的分解重组产物苯甲酰基芳胺. 产物结构经红外光谱、核磁共振谱和高分辨质谱表征.

关键词: 苯甲酰基硫脲, 氯乙酰氯, 二氯乙酰氯, 2-硫代咪唑啉-4-酮, 合成

3-Aryl-1-benzoylthiourea reacted with chloroacetye chloride to afford 1-aryl-3-benzoyl-2- thioxo-4-imidazolidinones in 70%～84% yields in the presence of alkaline. However, using dichloroacetye chloride instead of chloroacetye chloride, 1-aryl-3-benzoyl-5-chloro-4-imidazolidinones were obtained in 36%～53% yields. The structures of the products were confirmed by IR, 1H NMR and HRMS techniques.

Key words: benzoylthiourea, chloroacetye chloride, dichloroacetye chloride, 2-thioxo-4-imidazolidinone, synthesis