有机化学 ›› 2012, Vol. 32 ›› Issue (07): 1327-1331.DOI: 10.6023/cjoc1202072 上一篇    下一篇

研究简报

1-芳甲酰基-3-[4-((2-氰基亚胺基-1,3-噻唑烷-3-基)甲基)-噻唑-2-基]硫脲的合成及其生物活性研究

戴红a,b, 苗文科a, 刘建兵a, 吴珊珊a, 秦雪a, 张欣a, 方建新a   

  1. a 南开大学元素有机化学国家重点实验室 天津 300071;
    b 南通大学化学化工学院 南通 226019
  • 收稿日期:2012-02-07 修回日期:2012-04-26 发布日期:2012-05-11
  • 通讯作者: 戴红, 方建新 E-mail:daihong_2001@yahoo.com.cn; fjx@nankai.edu.cn
  • 基金资助:
    国家自然科学基金(No. 20772068);南通市科技计划(Nos. AS2010005)资助项目.

Synthesis and Biological Activity of 1-Aroyl-3-[4-((2-Cyanoimino-1,3-thiazolidine- 3-yl)methyl)-thiazol-2-yl]Thioureas

Dai Honga,b, Miao Wenkea, Liu Jianbinga, Wu Shanshana, Qin Xuea, Zhang Xina, Fang Jianxina   

  1. a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
    b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
  • Received:2012-02-07 Revised:2012-04-26 Published:2012-05-11
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 20772068) and the Science and Technology Project Fund of Nantong City (No. AS2010005).

为了寻找高活性的杂环农药, 将酰基硫脲骨架引入到噻唑分子结构中, 设计合成了14个未见文献报道的1-取代苯甲酰基-3-[4-((2-氰基亚胺基-1,3-噻唑烷-3-基)甲基)-噻唑-2-基]硫脲类化合物. 采用核磁共振氢谱和元素分析确认了新化合物的结构. 初步的生物活性测试结果表明, 部分标题化合物显示出一定的杀菌、植物生长调节或除草活性.

关键词: 噻唑, 酰基硫脲, 合成, 生物活性

In order to explore potent pesticide containing heterocycle, fourteen new 1-aroyl-3-[4-((2-cyanoimino-1,3-thiazolidine-3-yl)methyl)-thiazol-2-yl]thiourea compounds were designed and synthesized by introducing the important acylthiourea moiety into the molecular structure of thiazole. Their structures were identified by 1H NMR spectra and elemental analysis. The preliminary bioassay revealed that some compounds showed certain fungicidal, plant growth regulatory or herbicidal activities.

Key words: thiazole, acylthiourea, synthesis, biological activity