有机化学 ›› 2012, Vol. 32 ›› Issue (9): 1605-1619.DOI: 10.6023/cjoc201204008 上一篇    下一篇

综述与进展

苯并啡啶类生物碱及其衍生物合成研究进展

程辟a, 曾建国a,b   

  1. a 湖南农业大学 作物种质资源创新与资源利用国家重点实验室培育基地 长沙 410128;
    b 湖南农业大学 国家中药材生产(湖南)技术中心 长沙 410128
  • 收稿日期:2012-04-06 修回日期:2012-05-11 发布日期:2012-05-01
  • 通讯作者: 曾建国 E-mail:ginkgo@world-way.net
  • 基金资助:

    科技部国际科技合作计划(No.2010DFA32810)资助项目

Progresses in Synthesis of Benzophenanthridine Alkaloids and Their Derivatives

Cheng Pia, Zeng Jianguoa,b   

  1. a Pre-State Key Laboratory for Germplasm Innovation and Utilization of Crop, Hunan Agricultural University, Changsha 410128;
    b National Chinese Medicinal Herbs (Hunan) Technology Center, Hunan Agricultural University, Hunan Agricultural University, Changsha 410128
  • Received:2012-04-06 Revised:2012-05-11 Published:2012-05-01
  • Supported by:

    Project supported by the International Scientific and Technological Cooperation Program of State Ministry of Science and Technology (No.2010DFA32810)

苯并啡啶类生物碱是一类广泛分布于罂粟科和芸香科植物中的天然含氮化合物,具有显著的抗肿瘤和广谱抗菌等多种生物活性.基于苯并啡啶类生物碱的生源合成途径的特殊性对天然苯并啡啶类生物碱结构类型进行了分类.综述了自1999年以来天然苯并啡啶类生物碱及其衍生物的合成方法研究进展,对各个合成路线的特点进行了讨论.

关键词: 苯并啡啶类生物碱, 衍生物, 合成, 研究进展

Benzophenanthridine alkaloids are a small family of natural N-containing compounds that widely distribute in papaveraceous and rutaceous plants and display obvious antitumor and antibacterial activities. In this review, the structure types of natural benzophenanthridine alkaloids are classified based on the particularity of biosynthetic pathway of this group of alkaloids. The synthetic methods of benzophenanthridine alkaloids and related derivatives from 1999 are reviewed with discussion on particularity of each synthetic route.

Key words: benzophenanthridine alkaloids, derivatives, synthesis, progresses