有机化学 ›› 2013, Vol. 33 ›› Issue (11): 2435-2439.DOI: 10.6023/cjoc201305053 上一篇    下一篇

研究简报

酰胺为氮源的氨化反应及其机理

徐娟, 李加荣, 魏真, 张奇, 史大昕   

  1. 北京理工大学化工与环境学院 北京 100081
  • 收稿日期:2013-06-04 修回日期:2013-06-21 发布日期:2013-07-10
  • 通讯作者: 史大昕 E-mail:shidaxin@bit.edu.cn

Amide as Nitrogen Source: Amination and Mechanism

Xu Juan, Li Jiarong, Wei Zhen, Zhang Qi, Shi Daxin   

  1. School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081
  • Received:2013-06-04 Revised:2013-06-21 Published:2013-07-10

通过实验证明酰胺作为氮源在分子中引入胺基时,首先发生酰胺碳氮键的断裂生成胺的Lewis酸复合物,该复合物再与底物发生反应生成新的碳氮键. 以酰胺为氮源,在Lewis酸的配合下,将卤代芳烃、芳香三氟甲磺酸酯、硼酸、芳香硅化物和苯并唑类化合物胺化,证实这种新胺化方法具有很好的普适性.

关键词: 酰胺, 氮源, 有机胺的Lewis酸复合物, 机理, 碳氮键断裂和构建

The mechanism of C—N bond formation with amide as nitrogen source was disclosed. The process included the cleavage of amide C—N bond to form amine and then to construct new C—N bond. With the cooperation of Lewis acid, aryl halides, aryl triflates, boronic acids, aryl siloxanes and azoles could be aminated by amide as nitrogen source.

Key words: amide, nitrogen source, Lewis acid complex of amine, cleavage and formation of C—N bond