有机化学 ›› 2014, Vol. 34 ›› Issue (5): 962-967.DOI: 10.6023/cjoc201310018 上一篇    下一篇

研究论文

菲啶类化合物的合成新方法

马丽芳, 吕文贤, 黄丹凤, 牛腾, 苏瀛鹏, 王克虎, 胡雨来   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2013-10-15 修回日期:2013-12-10 发布日期:2014-01-15
  • 通讯作者: 黄丹凤 E-mail:huangdf@nwnu.edu.cn;wangkh@nwnu.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21062016)资助项目.

A New Method for the Synthesis of Phenanthridine Compounds

Ma Lifang, L? Wenxian, Huang Danfeng, Niu Teng, Su Yingpeng, Wang Kehu, Hu Yulai   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2013-10-15 Revised:2013-12-10 Published:2014-01-15
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21062016).

探索了5-甲氧基菲啶-6(5H)-酮化合物与芳基格氏试剂的反应,得到了菲啶类化合物. 该方法反应条件温和,操作简便,产率较好,提供了一种合成菲啶衍生物的新方法. 但是,当烷基溴化镁与5-甲氧基菲啶-6(5H)-酮化合物反应时,只得到了菲啶-6(5H)-酮类化合物.

关键词: 菲啶, 5-甲氧基菲啶-6(5H)-酮, Weinreb酰胺, 格氏试剂, 合成

5-Methoxyphenanthridin-6(5H)-ones reacted with aryl Grignard reagents to afford phenanthridine compounds. The method has the advantages of mild reaction conditions with good yields and provides a new synthetic procedure for the phenanthridine derivatives. However, the products were phenanthridin-6(5H)-ones when alkyl magnesium bromide reacted with 5-methoxyphenanthridin-6(5H)-ones.

Key words: phenanthridines, 5-methoxyphenanthridin-6(5H)-ones, Weinreb amides, Grignard reagents, synthesis