有机化学 ›› 2015, Vol. 35 ›› Issue (5): 947-960.DOI: 10.6023/cjoc201411003 上一篇    下一篇

综述与进展

氧头孢衍生物不对称合成的研究进展

付冬君a, 刘英超a, 李锋a, 张恩a, 刘宏民a,b   

  1. a 郑州大学药学院 郑州 450001;
    b 郑州大学新药研发中心 郑州 450001
  • 收稿日期:2014-11-03 修回日期:2014-12-12 发布日期:2015-01-07
  • 通讯作者: 刘宏民 E-mail:liuhm@zzu.edn.cn
  • 基金资助:

    国家自然科学基金(No.81172937)资助项目.

Recent Advances in Asymmetric Synthesis of Oxacephems

Fu Dongjuna, Liu Yingchaoa, Li Fenga, Zhang Ena, Liu Hongmina,b   

  1. a School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001;
    b New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001
  • Received:2014-11-03 Revised:2014-12-12 Published:2015-01-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.81172937).

氧头孢是β-内酰胺类药物的代表性母核, 其衍生物显著的生物学活性和合成的复杂性对药物化学家极具吸引力. 以氧头孢合成中使用的关键方法分类, 对氧头孢的合成研究进展进行了综述.

关键词: 氧头孢烯, 氧头孢烷, 不对称合成, 抗生素

The oxacephems is unique among β-lactams. Due to the interesting biological activity and complex synthesis, its derivatives have attracted immense interest for medicinal chemists. Progresses toward the synthesis of oxacephems were reviewed in terms of the key strategies employed.

Key words: oxacephem, oxacepham, asymmitric synthesis, antibiotic