有机化学 ›› 2015, Vol. 35 ›› Issue (8): 1585-1597.DOI: 10.6023/cjoc201503025 上一篇    下一篇

综述与进展

巴西木素类天然产物的合成研究进展

汪学全a,b, 刘卫a, 段素月a, 羊晓东b, 张洪彬b   

  1. a 红河学院理学院/云南省天然药物与化学生物学重点实验室 蒙自 661199;
    b 云南大学教育部自然资源药物化学重点实验室 昆明 650091
  • 收稿日期:2015-03-17 修回日期:2015-05-03 发布日期:2015-05-14
  • 通讯作者: 羊晓东, 张洪彬 E-mail:xdyang@ynu.edu.cn;zhanghb@ynu.edu.cn
  • 基金资助:

    长江学者和创新团队发展计划(No. IRT13095)、国家自然科学基金(Nos. 21462049, 21332007, U1402227)、云南省自然科学基金(Nos. 2013FA028, 2012FB113)、云南大学青年英才培育计划资助项目.

Research Progress on the Synthesis of Brazilin-Type Natural Products

Wang Xuequana,b, Liu Weia, Duan Suyuea, Yang Xiaodongb, Zhang Hongbinb   

  1. a Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province/School of Science, Honghe University, Mengzi 661199;
    b Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, Yunnan University, Kunming 650091
  • Received:2015-03-17 Revised:2015-05-03 Published:2015-05-14
  • Supported by:

    Project supported by the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT13095), the National Natural Science Foundation of China (Nos. 21462049, 21332007, U1402227), the Natural Science Foundation of Yunnan Province (Nos. 2013FA028, 2012FB113) and the Excellent Young Talents of Yunnan University.

巴西木素类型天然产物是从中药苏木(Caesalpinia sappan)中分离得到的一类化合物, 因其独特的结构和良好的生物活性而成为合成化学家关注的焦点. 目前, 已有许多关于这类天然产物合成的报道. 我们主要对巴西木素类型天然产物的合成研究进展进行了综述.

关键词: 巴西木素, Brazilide A, Brazilein, 合成

Brazilin-type natural products were isolated from the heartwood of Caesalpinia sappan, a famous traditional Chinese medicine. These compounds have stimulated a great deal of interest on synthetic chemists due to their structural novelty and promising biological activities. Up to now, many methods towards the synthesis of these natural products have been developed. Progress on the synthesis of Brazilin-type natural products are reviewed in this paper.

Key words: brazilin, brazilide A, brazilein, synthesis