有机化学 ›› 2016, Vol. 36 ›› Issue (2): 432-436.DOI: 10.6023/cjoc201508030 上一篇    下一篇

研究简报

3-C位单取代环维黄杨星D衍生物的合成及其抗耐缺氧活性研究

向涛, 杨鸿均, 陈程, 冯豫川   

  1. 西南民族大学化学与环境保护工程学院 成都 610041
  • 收稿日期:2015-08-30 修回日期:2015-10-03 发布日期:2015-10-13
  • 通讯作者: 杨鸿均, 冯豫川 E-mail:yanghj@swun.cn
  • 基金资助:

    西南民族大学研究生创新型科研(No. CX2014SZ60)、西南民族大学中央高校基本科研业务费专项资金(No. 2014NZYQN21)资助项目

Synthesis and Anti-anoxia Activities of 3-C Mono-substituted Cyclovirobuxine D Derivatives

Xiang Tao, Yang Hongjun, Chen Cheng, Feng Yuchuan   

  1. College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041
  • Received:2015-08-30 Revised:2015-10-03 Published:2015-10-13
  • Supported by:

    Project supported by the Southwest University for Nationalities Graduate Student Innovative Projects (No. CX2014SZ60), and the Fundamental Research Funds for the Central Universities (No. 2014NZYQN21).

以植物活性单体环维黄杨星D为先导物, 设计合成了7个新型的含氮杂环的环维黄杨星D衍生物, 其结构经1H NMR, HRMS和IR鉴定. 初步的抗耐缺氧活性研究结果表明, 合成的新化合物具有一定的抗耐缺氧活性, 其中含哌嗪基取代的衍生物活性较好.

关键词: 环维黄杨星D, 合成, 抗耐缺氧活性

Seven novel cyclovirobuxine D derivatives were designed and synthesized by using cyclovirobuxine D as a starting material. All compounds synthesized were confirmed by 1H NMR, HRMS and IR. Preliminary results of anti-anoxia activity indicated that compounds displayed different degrees of activity, among them the compounds with piperazinyl exhibited higher anti-anoxia activity than others.

Key words: cyclovirobuxine D, synthesis, anti-anoxia activity