有机化学 ›› 2017, Vol. 37 ›› Issue (10): 2526-2543.DOI: 10.6023/cjoc201703017 上一篇    下一篇

综述与进展

具有优良抗癌活性的天然产物Neopeltolide的合成研究进展

于江帆, 冯若昆, 杨震   

  1. 绍兴文理学院化学化工学院 浙江省精细化学品传统工艺替代技术研究重点实验室 绍兴 312000
  • 收稿日期:2017-03-08 修回日期:2017-06-07 发布日期:2017-06-16
  • 通讯作者: 杨震 E-mail:yangzhen09@usx.edu.cn
  • 基金资助:

    国家自然科学基金(No.21302129)和浙江省自然科学基金(No.LQ13B020002)资助项目.

Synthetic Studies toward Neopeltolide:A Potent Anti-cancer Natural Product

Yu Jiangfan, Feng Ruokun, Yang Zhen   

  1. Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Department of Chemistry, Shaoxing University, Shaoxing, Zhejiang Province 312000
  • Received:2017-03-08 Revised:2017-06-07 Published:2017-06-16
  • Contact: 10.6023/cjoc201703017 E-mail:yangzhen09@usx.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21302129) and the Natural Science Foundation of Zhejiang Province (No.LQ13B020002).

(+)-Neopeltolide是Wright小组从海洋的neopeltidae类深水海绵中分离得到了大环内酯化合物.该分子具有非常新颖的结构特征和非常优良的抗癌活性,到目前为止已经有二十多篇关于neopeltolide的合成论文报道,包括全合成和大环内酯骨架的合成.根据neopeltolide的合成策略的差异进行了简要的综述,主要分为全合成、大环内酯骨架合成、neopeltolide类似物合成等几个方面.

关键词: (+)-Neopeltolide, 大环内酯, 抗癌, 大环内酯化反应, Prins环化反应, 烯烃复分解反应

(+)-Neopeltolide was isolated from a deep-water sponge of the family neopeltidae. Due to its attractive novel structure and highly potent anticancer activity, more than twenty total and formal syntheses have been reported in last decade. Herein, the synthetic studies toward the total and formal syntheses of neopeltolide are reviewed according to the synthetic strategies toward the macrolactone core.

Key words: (+)-neopeltolide, macrolactone, anti-cancer, macrolactonization, prins cyclization, olefin metathesis