通过1,3-二芳基-1,3-二酮合成α,α,γ,γ-四氟-β-羟基酮和α-氟代苯乙酮

doi:10.6023/cjoc201910014

有机化学 ›› 2020, Vol. 40 ›› Issue (4): 930-937.DOI: 10.6023/cjoc201910014 上一篇下一篇

研究论文

通过1,3-二芳基-1,3-二酮合成α,α,γ,γ-四氟-β-羟基酮和α-氟代苯乙酮

鲍堃^a,b, 危俊^b, 盛荣^b

a 浙江工业大学长三角绿色制药协同创新中心杭州 310014;
b 浙江大学药学院杭州 310058

收稿日期:2019-10-11 修回日期:2019-12-07 发布日期:2019-12-27
通讯作者: 盛荣 E-mail:shengr@zju.edu.cn

Synthesis of α,α,γ,γ-Tetrafluoro-β-hydroxy Ketones and α-Fluoroacetophenones via 1,3-Diaryl-1,3-diketones

Bao Kun^a,b, Wei Jun^b, Sheng Rong^b

a Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014;
b College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058

Received:2019-10-11 Revised:2019-12-07 Published:2019-12-27

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摘要/Abstract

α，α，γ，γ-四氟-β-羟基酮和α-氟代苯乙酮两类化合物被广泛运用于有机化学、农业化学以及制药等领域.开发了一种从1，3-二芳基-1，3-二酮合成α，α，γ，γ-四氟-β-羟基酮和α-氟代苯乙酮的温和且有效的方法.通过改变反应条件，可以分别以中等至良好的产率获得两种不同的产物.

关键词: α,α,γ,γ-四氟-β-羟基酮, α-氟代苯乙酮, 1,3-二芳基-1,3-二酮

α,α,γ,γ-Tetrafluoro-β-hydroxy ketones and α-fluoroacetophenones are widely used in the fields of organic chemistry, agrochemicals, and pharmaceuticals. A mild and excellent method to synthesize α,α,γ,γ-tetrafluoro-β-hydroxy ketones and α-fluoroacetophenones via various 1,3-diaryl-1,3-diketones has been developed. With the modification of reaction conditions, two different products could be obtained in moderate to good yields, respectively.

Key words: α,α,γ,γ-tetrafluoro-β-hydroxy ketones, α-fluoroacetophenones, 1,3-diaryl-1,3-diketones

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鲍堃, 危俊, 盛荣. 通过1,3-二芳基-1,3-二酮合成α,α,γ,γ-四氟-β-羟基酮和α-氟代苯乙酮[J]. 有机化学, 2020, 40(4): 930-937.

Bao Kun, Wei Jun, Sheng Rong. Synthesis of α,α,γ,γ-Tetrafluoro-β-hydroxy Ketones and α-Fluoroacetophenones via 1,3-Diaryl-1,3-diketones[J]. Chinese Journal of Organic Chemistry, 2020, 40(4): 930-937.

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通过1,3-二芳基-1,3-二酮合成α,α,γ,γ-四氟-β-羟基酮和α-氟代苯乙酮

Synthesis of α,α,γ,γ-Tetrafluoro-β-hydroxy Ketones and α-Fluoroacetophenones via 1,3-Diaryl-1,3-diketones

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