有机化学 ›› 2021, Vol. 41 ›› Issue (1): 229-240.DOI: 10.6023/cjoc202006003 上一篇    下一篇

综述与进展

亚铁离子荧光探针的研究进展

马素芳a,c, 余强b, 陆利a, 李丽红a, 刘文a,c, 武志芳b,c,*(), 李思进b,c,*()   

  1. a 山西医科大学基础医学院 太原 030001
    b 山西医科大学医学影像学院 太原 030001
    c 山西医科大学第一医院核医学科 太原 030001
  • 收稿日期:2020-06-02 修回日期:2020-07-10 发布日期:2020-08-01
  • 通讯作者: 武志芳, 李思进
  • 作者简介:
    * Corresponding authors. E-mail: ;
  • 基金资助:
    山西省青年科技研究基金(201901D211348); 山西省高等学校科技创新(2019L0409); 山西省高等学校科技创新(2019L0444); 山西医科大学博士启动基金(BS03201609)

Recent Progress in Fluorescent Probes for the Detection of Ferrous Ion

Sufang Maa,c, Qiang Yub, Li Lua, Lihong Lia, Wen Liua,c, Zhifang Wub,c,*(), Sijin Lib,c,*()   

  1. a School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001
    b Medical Imaging Department, Shanxi Medical University, Taiyuan 030001
    c Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001
  • Received:2020-06-02 Revised:2020-07-10 Published:2020-08-01
  • Contact: Zhifang Wu, Sijin Li
  • Supported by:
    the Youth Science Foundation of Shanxi Province(201901D211348); the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province(2019L0409); the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province(2019L0444); the Ph. D Startup Fund of Shanxi Medical University(BS03201609)

铁作为生命系统中最丰富的过渡金属元素, 在许多生理和病理过程中发挥着无可替代的作用. 铁平衡失调不仅会导致诸如癌症、心血管疾病、神经退行性疾病等的发生和发展, 而且还会造成细胞铁死亡. 尽管细胞中的铁有Fe 2+和Fe 3+两种形式, 但细胞还原性微环境使其主要以Fe 2+形式存在. 因此, 开发一种对Fe 2+的特异性检测技术有助于深入了解Fe 2+与人类健康和疾病的关系. 随着荧光成像技术的发展, 近年来特异性检测Fe 2+的荧光探针引起学者们的极大关注. 对近10年来报道的Fe 2+荧光探针, 根据探针的设计思路、与Fe 2+的作用机理、光学特性以及其生物应用等方面进行了总结, 并对Fe 2+荧光探针的发展前景进行了展望.

关键词: 亚铁离子, 荧光探针, 荧光成像

Irons, as the most abundant transition metal in living system, play an irreplaceable role in many physiological and pathological processes. The misregulation of Fe 2+ homeostasis not only affects the occurence and delelopment of various diseases, such as cancer, cardiovascular disease and neurodegenerative disorders, but also induces ferroptosis. Although two forms of iron (Fe 2+ and Fe 3+) exist in cells, reducing microenvironment of cells makes it exist mainly in the form of Fe 2+. Therefore, developing a sensitive approach for Fe 2+ is particularly important because it may contribute to the in-depth understanding of the relationship between Fe 2+ and human health and disease. In recent years, with the rapid development of fluorescent imaging technique, fluorescent probes for the sensitive detection of Fe 2+ have attracted great interest. Fe 2+ fluorescent probes reported in the last ten years are summarized, according to probes design, sensing mechanisms with Fe 2+, optical properties and biological application. In addition, the development prospect of Fe 2+ fluorescent probes is predicted.

Key words: s ferrous ion, fluorescent probe, fluorescent imaging