有机化学 ›› 2021, Vol. 41 ›› Issue (4): 1572-1581.DOI: 10.6023/cjoc202101009 上一篇 下一篇
所属专题: 热点论文虚拟合集
研究论文
收稿日期:
2021-01-05
修回日期:
2021-01-25
发布日期:
2021-02-22
通讯作者:
徐森苗
基金资助:
Luhua Liua,b, Rongrong Dua,b, Senmiao Xua,*()
Received:
2021-01-05
Revised:
2021-01-25
Published:
2021-02-22
Contact:
Senmiao Xu
About author:
Supported by:
文章分享
报道了无外加配体参与的以吡唑作为导向基团的铱催化的sp3碳氢键的区域选择性硼化反应. 在催化量的[Ir(OMe)(cod)]2存在下, 该反应能够顺利地将苄位的二级碳氢键转化成碳硼键. 该反应具有非常广谱的官能团兼容性, 能够以良好到优秀的产率生成相应的产物. 此外, 导向基团吡唑能够通过臭氧接转化成酰胺.
刘路华, 杜荣荣, 徐森苗. 无配体参与的铱催化的苄位二级碳氢键的硼化反应[J]. 有机化学, 2021, 41(4): 1572-1581.
Luhua Liu, Rongrong Du, Senmiao Xu. Ligand-Free Iridium-Catalyzed Borylation of Secondary Benzylic C—H Bonds[J]. Chinese Journal of Organic Chemistry, 2021, 41(4): 1572-1581.
Entrya | Variation from standard conditions | Yieldb/% of 3 |
---|---|---|
1 | None | 90 |
2 | [IrCl(cod)]2 instead of [IrOMe(cod)]2 | 81 |
3 | HBpin instead of B2pin2 | Trace |
4 | 1.0 equiv of B2pin2 was used | 50 |
5 | 2 mol% dtbpy was used | n.d. |
6 | 2 mol% P(C6F5)3 was used | 80 |
7 | 80 ℃ instead of 100 ℃ | 60 |
8 | 1,4-Dioxane instead of n-heptane | 33 |
9 | n-Hexane instead of n-heptane | 77 |
Entrya | Variation from standard conditions | Yieldb/% of 3 |
---|---|---|
1 | None | 90 |
2 | [IrCl(cod)]2 instead of [IrOMe(cod)]2 | 81 |
3 | HBpin instead of B2pin2 | Trace |
4 | 1.0 equiv of B2pin2 was used | 50 |
5 | 2 mol% dtbpy was used | n.d. |
6 | 2 mol% P(C6F5)3 was used | 80 |
7 | 80 ℃ instead of 100 ℃ | 60 |
8 | 1,4-Dioxane instead of n-heptane | 33 |
9 | n-Hexane instead of n-heptane | 77 |
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