有机化学 ›› 2021, Vol. 41 ›› Issue (7): 2610-2620.DOI: 10.6023/cjoc202103020 上一篇    下一篇

所属专题: 热点论文虚拟合集

综述与进展

铱催化的(杂)芳烃远端区域选择性C—H硼化反应的最新进展

邹晓亮a,b, 徐森苗a,*()   

  1. a 中国科学院兰州化学物理研究所 羰基合成与选择氧化国家重点实验室 兰州 730000
    b 中国科学院大学 北京 100049
  • 收稿日期:2021-03-10 修回日期:2021-03-17 发布日期:2021-03-25
  • 通讯作者: 徐森苗
  • 基金资助:
    国家自然科学基金(91956116)

Recent Progress in Iridium-Catalyzed Remote Regioselective C—H Borylation of (Hetero)Arenes

Xiaoliang Zoua,b, Senmiao Xua()   

  1. a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000
    b University of Chinese Academy of Sciences, Beijing 100049
  • Received:2021-03-10 Revised:2021-03-17 Published:2021-03-25
  • Contact: Senmiao Xu
  • Supported by:
    National Natural Science Foundation of China(91956116)

(杂)芳基硼酸及其衍生物在合成化学、材料科学和药物化学领域具有广泛的用途, 因此, 其合成方法研究一直备受关注. 铱催化的C—H硼化反应是合成这类化合物最为有效的途径之一, 然而, 由于反应机理的限制, 区域选择性可控的C—H硼化是铱催化体系的一大挑战, 同时也是该领域的一个重要发展方向. 系统介绍了最近几年铱催化的芳烃远端硼氢化反应的最新进展.

关键词: 碳氢键活化, (杂)芳基硼酸酯, 合成方法, 硼化

(Hetero)Aryl boronic acids and their derivatives have been widely used in synthetic chemistry, material sciences, and drug discovery. Accordingly, the development of novel synthetic methods towards these structures has received a great deal of attention. In particular, Ir-catalyzed C—H borylation represents one of the most efficient methods. Due to the restriction of the reaction mechanism, regioselective controllable C—H borylation of Ir catalysis is a formidable challenge, and it is also an important development direction in this area. In this review, the recent progress in Ir-catalyzed remote selective C—H borylation of arenes is systematically discussed.

Key words: C—H activation, (hetero)aryl boronates, synthetic methods, borylation